Evidence map›Paper›PMID 34360779›Full record

ArticleInternational journal of molecular sciences2021

Divalent Metal Transporter 1 Knock-Down Modulates IL-1β Mediated Pancreatic Beta-Cell Pro-Apoptotic Signaling Pathways through the Autophagic Machinery.

Taewook Kang, Honggang Huang, Thomas Mandrup-Poulsen, Martin R Larsen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Taewook KangProtein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Honggang HuangProtein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Thomas Mandrup-PoulsenImmuno-Endocrinology Laboratory, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.ORCID 0000-0002-3215-9273
Martin R LarsenProtein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
University of Southern Denmark · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pro-inflammatory cytokines promote cellular iron-import through enhanced divalent metal transporter-1 (

Indexed as

Gene Knockdown TechniquesAnimalsApoptosisAutophagyCation Transport ProteinsInsulin-Secreting CellsInterleukin-1betaInterleukin-6MiceSignal TransductionSolute Carrier Family 11, Member 2Cation Transport ProteinsIL1B protein, mouseInterleukin-1betaInterleukin-6interleukin-6, mouseSolute Carrier Family 11, Member 2anti-apoptosisautophagycell cycle arrestdiabetesiron metabolismROS

Identifiers

PMID34360779
PMCPMC8348373
OpenAlexW3185236734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.