Evidence map›Paper›PMID 34360757›Full record

ArticleInternational journal of molecular sciences2021

Targeting the Highly Expressed microRNA miR-146b with CRISPR/Cas9n Gene Editing System in Thyroid Cancer.

Daniel Casartelli de Santa-Inez, Cesar Seigi Fuziwara, Kelly Cristina Saito, Edna Teruko Kimura

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  10. Using CRISPR/Cas9 to Edit a Thyroid Cancer Cell Line.Advances in experimental medicine and biology · 2023
    Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Daniel Casartelli de Santa-InezDepartment of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.ORCID 0000-0003-3896-0712
Cesar Seigi FuziwaraDepartment of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.ORCID 0000-0002-0567-5432
Kelly Cristina SaitoDepartment of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.ORCID 0000-0001-6397-6754
Edna Teruko KimuraDepartment of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.ORCID 0000-0001-8403-4459
Universidade de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 430756/2018-6Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Code 001Coordenação de Aperfeiçoamento de Pessoal de Nível Superior PNPD 88887.374682/2019-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/17282-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/19865-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/25116-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/10403-9Universidade de São Paulo NapmiR
6 · The paper itself

Abstract

Thyroid cancer is the most common endocrine malignancy, and the characterization of the genetic alterations in coding-genes that drive thyroid cancer are well consolidated in MAPK signaling. In the context of non-coding RNAs, microRNAs (miRNAs) are small non-coding RNAs that, when deregulated, cooperate to promote tumorigenesis by targeting mRNAs, many of which are proto-oncogenes and tumor suppressors. In thyroid cancer,

Indexed as

CRISPR-Cas SystemsGene EditingGene TargetingMicroRNAsRNA, NeoplasmThyroid Carcinoma, AnaplasticThyroid NeoplasmsAnimalsCell LineCell MovementCell SurvivalHeterograftsHumansMiceNeoplasm TransplantationMicroRNAsMIRN146 microRNA, humanRNA, Neoplasmanaplastic thyroid cancerCRISPR/Cas9ngene editingmicroRNAmiR-146b

Identifiers

PMID34360757
PMCPMC8348963
OpenAlexW3183255180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.