Evidence map›Paper›PMID 34360719›Full record

ReviewInternational journal of molecular sciences2021

Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A

Elisabetta Coppi, Federica Cherchi, Elena Lucarini, Carla Ghelardini, Felicita Pedata, Kenneth A Jacobson, Lorenzo Di Cesare Mannelli, Anna Maria Pugliese, Daniela Salvemini

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Lipid Trolling to Optimize AJournal of medicinal chemistry · 2024
    Article
  5. 2-Substituted (N)-Methanocarba AACS pharmacology & translational science · 2024
    Article
  6. Article
  7. Article
  8. Covalently Binding Adenosine APurinergic signalling · 2024
    Article
  9. Unraveling the enigma: housekeeping geneFrontiers in psychiatry · 2024
    Article
  10. Review
  11. Review
  12. Species dependence of APurinergic signalling · 2023
    Review
  13. Article
  14. Adenosine Receptors as Potential Therapeutic Analgesic Targets.International journal of molecular sciences · 2023
    Review
  15. Article
  16. SIRT1: A promising therapeutic target for chronic pain.CNS neuroscience & therapeutics · 2022
    Review
  17. Review
  18. Targeting the AActa neuropathologica communications · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Elisabetta CoppiDepartment NEUROFARBA, Division of Pharmacology and Toxicology, University of Florence, 50139 Firenze, Italy.ORCID 0000-0003-4434-5919
Federica CherchiDepartment NEUROFARBA, Division of Pharmacology and Toxicology, University of Florence, 50139 Firenze, Italy.ORCID 0000-0001-6742-456X
Elena LucariniDepartment NEUROFARBA, Division of Pharmacology and Toxicology, University of Florence, 50139 Firenze, Italy.ORCID 0000-0002-3459-2660
Carla GhelardiniDepartment NEUROFARBA, Division of Pharmacology and Toxicology, University of Florence, 50139 Firenze, Italy.
Felicita PedataDepartment NEUROFARBA, Division of Pharmacology and Toxicology, University of Florence, 50139 Firenze, Italy.
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, USA.ORCID 0000-0001-8104-1493
Lorenzo Di Cesare MannelliDepartment NEUROFARBA, Division of Pharmacology and Toxicology, University of Florence, 50139 Firenze, Italy.ORCID 0000-0001-8374-4432
Anna Maria PuglieseDepartment NEUROFARBA, Division of Pharmacology and Toxicology, University of Florence, 50139 Firenze, Italy.
Daniela SalveminiDepartment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
University of Florence · ITNational Institutes of Health · USSaint Louis University · US

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Fondazione Italiana Sclerosi Multipla 2019/R-Single/036NIDDK NIH HHS ZIADK31117NIH HHS NIH/NCI R01 CA169519University of Florence Fondi Ateneo
6 · The paper itself

Abstract

Agonists of the G

Indexed as

Ganglia, SpinalPainAdenosine A3 Receptor AgonistsAnimalsAstrocytesCalcium SignalingHumansMicrogliaReceptor, Adenosine A3Adenosine A3 Receptor AgonistsADORA3 protein, humanReceptor, Adenosine A3A3 adenosine receptoradenosineCa2+ currentsdorsal root ganglion neuronsinterleukin-10neuropathic painT cellsvisceral pain

Identifiers

PMID34360719
PMCPMC8347395
OpenAlexW3184102753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.