Evidence map›Paper›PMID 34360704›Full record

ArticleInternational journal of molecular sciences2021

Memantine Prevents the WIN 55,212-2 Evoked Cross-Priming of Ethanol-Induced Conditioned Place Preference (CPP).

Marta Marszalek-Grabska, Irena Smaga, Paulina Surowka, Pawel Grochecki, Tymoteusz Slowik, Malgorzata Filip, Jolanta H Kotlinska

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Marta Marszalek-GrabskaDepartment of Experimental and Clinical Pharmacology, Medical University of Lublin, 20-090 Lublin, Poland.ORCID 0000-0002-2487-9131
Irena SmagaDepartment of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland.ORCID 0000-0002-7783-8181
Paulina SurowkaAffective Cognitive Neuroscience Laboratory, Department of Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland.
Pawel GrocheckiDepartment of Pharmacology and Pharmacodynamics, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0003-0591-3645
Tymoteusz SlowikExperimental Medicine Center, Medical University of Lublin, 20-090 Lublin, Poland.ORCID 0000-0001-8758-6240
Malgorzata FilipDepartment of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland.
Jolanta H KotlinskaDepartment of Pharmacology and Pharmacodynamics, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-4178-1515
Medical University of Lublin · PLMaj Institute of Pharmacology · PL

Funding

Uniwersytet Medyczny w Lublinie DS 22/21
6 · The paper itself

Abstract

The activation of the endocannabinoid system controls the release of many neurotransmitters involved in the brain reward pathways, including glutamate. Both endocannabinoid and glutamate systems are crucial for alcohol relapse. In the present study, we hypothesize that N-methyl-D-aspartate (NMDA) glutamate receptors regulate the ability of a priming dose of WIN 55,212-2 to cross-reinstate ethanol-induced conditioned place preference (CPP). To test this hypothesis, ethanol-induced (1.0 g/kg, 10%

Indexed as

AnimalsBenzoxazinesConditioning, PsychologicalEthanolMaleMemantineMorpholinesMotivationNaphthalenesRatsRats, Wistar(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanoneBenzoxazinesEthanolMemantineMorpholinesNaphthalenescannabinoidCNR1ethanol relapseglutamateGRIN1GRIN2Arats

Identifiers

PMID34360704
PMCPMC8348856
OpenAlexW3184178649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.