SynthesisInternational journal of molecular sciences2021
Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic Review.
Synthesis in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 65 citations in OpenAlex.
- Antinociceptive and Anti-Inflammatory Effects of Syringic Acid:ACS omega · 2026Article
- Esculetin attenuates migraine-like pain via CGRP suppression and meningeal mast cell modulation in rat models.Journal of Zhejiang University. Science. B · 2026Article
- Characterization of Heterotrigona itama Propolis Extracts: Phytochemicals and Thermal Insights.Chemistry & biodiversity · 2026Article
- In Vitro Effects of Minor Olive Oil Compounds on Prostacyclin/Thromboxane Balance Under Acute High-Glucose Conditions.Biomolecules · 2026Article
- Polyphenol Composition, Antioxidant Properties, and Health Benefits of Moroccan-Cultivated Raspberries, Blackberries, and Blueberries: A Comprehensive Review.Foods (Basel, Switzerland) · 2026Review
- Chemical profiling and biological activities of the medicinal macrofungus Coriolopsis gallica: volatile, non-volatile, and fatty acid composition with antioxidant and in silico-supported anti-inflammatory properties.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026Article
- Chemical Profiling, Analgesic and Anti-Inflammatory Activities ofPlants (Basel, Switzerland) · 2026Article
- Bioactive compounds in European ferns: inhibition of pro-inflammatory enzymes and cytotoxic effects on cancer cells.BMC complementary medicine and therapies · 2026Article
- Recent Advances in Dual COX/LOX Inhibitor Design (2020-2024): Establishing "Life (Basel, Switzerland) · 2026Review
- Novel Pyrazole-3-Cyano-2-Pyridinone Hybrids as Multitarget Anti-Inflammatory Agents: Synthesis, Computational Modeling, and Biological Evaluation.Drug design, development and therapy · 2026Article
- Impact of Psidium guajava bark extract on inflammatory biomarkers in Wistar rat models of inflammation.Inflammopharmacology · 2025Article
- Investigating Network and Experimental Effect of Silibinin on Lipin-1 and Lipin-2 Gene Expression during Ischemia-reperfusion of the Liver in Rats.Cell biochemistry and biophysics · 2025Article
- Bioactive compounds in the modulation of oxidative stress in monocytes and macrophages.Scientific reports · 2025Article
- Roles of Lipoxygenases in Cardiovascular Diseases.Journal of cardiovascular translational research · 2025Review
- Toxicity profiling and HR-LCMS analysis of3 Biotech · 2025Article
- Liver disorders and phytotherapy.Toxicology reports · 2025Review
- Electrospun Quercetin-Loaded PLA and PLA/Polyethylene Glycol Fibers: Preparation, Characterization, and In Vitro Evaluation.Pharmaceutics · 2025Article
- Vanillin Enhances Photobiomodulation Wound Healing by Modulating Glyco-Oxidative Stress and Glucose Dysmetabolism in Diabetic Wounded Fibroblast Cells.Journal of cellular and molecular medicine · 2025Article
- Natural solutions for glowing skin: spices.Frontiers in nutrition · 2025Review
- Dual anti-inflammatory activities of COX-2/5-LOX driven by kratom alkaloid extracts in lipopolysaccharide-induced RAW 264.7 cells.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
5-Lipoxygenase (5-LOX) plays a key role in inflammation through the biosynthesis of leukotrienes and other lipid mediators. Current evidence suggests that dietary (poly)phenols exert a beneficial impact on human health through anti-inflammatory activities. Their mechanisms of action have mostly been associated with the modulation of pro-inflammatory cytokines (TNF-α, IL-1β), prostaglandins (PGE
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.