Evidence map›Paper›PMID 34360700›Full record

ArticleInternational journal of molecular sciences2021

Maternal Neutrophil Depletion Fails to Avert Systemic Lipopolysaccharide-Induced Early Pregnancy Defects in Mice.

Sourav Panja, John T Benjamin, Bibhash C Paria

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sourav PanjaDivision of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
John T BenjaminDivision of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-0930-1753
Bibhash C PariaDivision of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-1183-8648

Funding

Mechanism and prevention of lipopolysaccharide-induced early pregnancy complicationsR01HD094946 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PARIA, BIBHASH CHANDRA · 2018 to 2022
$2.1M
Eunice Kennedy Shriver National Institute of Child Health and Human Development HD094946NICHD NIH HHS R01 HD094946
6 · The paper itself

Abstract

Maternal infection-induced early pregnancy complications arise from perturbation of the immune environment at the uterine early blastocyst implantation site (EBIS), yet the underlying mechanisms remain unclear. Here, we demonstrated in a mouse model that the progression of normal pregnancy from days 4 to 6 induced steady migration of leukocytes away from the uterine decidual stromal zone (DSZ) that surrounds the implanted blastocyst. Uterine macrophages were found to be CD206

Indexed as

Signal TransductionAnimalsCytokinesDisease Models, AnimalEmbryo ImplantationFemaleInflammationLipopolysaccharidesMacrophagesMiceMyeloid Differentiation Factor 88NeutrophilsPregnancyPregnancy Complications, InfectiousToll-Like Receptor 4CytokinesLipopolysaccharidesMyd88 protein, mouseMyeloid Differentiation Factor 88Tlr4 protein, mouseToll-Like Receptor 4chemokinescytokinesdecidual stromal zoneearly pregnancyimplantationleukocyteslipopolysaccharidenon-decidual stromal zoneuterus

Identifiers

PMID34360700
PMCPMC8347248

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.