Evidence map›Paper›PMID 34360697›Full record

ArticleInternational journal of molecular sciences2021

The Application of an Omentum Graft or Flap in Spinal Cord Injury.

Li-Yu Fay, Yan-Ru Lin, Dann-Ying Liou, Chuan-Wen Chiu, Mei-Yin Yeh, Wen-Cheng Huang, Jau-Ching Wu, May-Jywan Tsai, Henrich Cheng

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Two Faces of Greater Omentum.Comprehensive physiology · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Li-Yu FayInstitute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Taipei 11217, Taiwan.ORCID 0000-0003-0914-8776
Yan-Ru LinDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Room 525, 17F, No. 201, Sec. 2, Shipai Road, Taipei 11217, Taiwan.ORCID 0000-0003-2894-5551
Dann-Ying LiouDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Room 525, 17F, No. 201, Sec. 2, Shipai Road, Taipei 11217, Taiwan.
Chuan-Wen ChiuDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Room 525, 17F, No. 201, Sec. 2, Shipai Road, Taipei 11217, Taiwan.
Mei-Yin YehInstitute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Taipei 11217, Taiwan.
Wen-Cheng HuangInstitute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Taipei 11217, Taiwan.
Jau-Ching WuInstitute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Taipei 11217, Taiwan.ORCID 0000-0002-6996-3409
May-Jywan TsaiDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Room 525, 17F, No. 201, Sec. 2, Shipai Road, Taipei 11217, Taiwan.
Henrich ChengInstitute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Taipei 11217, Taiwan.
National Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TW

Funding

Ministry of Science and Technology, Taiwan MOST 108-2314-B-075-014Ministry of Science and Technology, TAIWAN MOST 107-2314-B-075-021Taipei Veterans General Hospital V105D6-001-MY3-3Taipei Veterans General Hospital V108C-036
6 · The paper itself

Abstract

backgroundSpinal cord injury (SCI) causes a primary injury at the lesion site and triggers a secondary injury and prolonged inflammation. There has been no definitive treatment till now. Promoting angiogenesis is one of the most important strategies for functional recovery after SCI. The omentum, abundant in blood and lymph vessels, possesses the potent ability of tissue regeneration.

methodsThe present work examines the efficacy of autologous omentum, either as a flap (with vascular connection intact) or graft (severed vascular connection), on spinal nerve regeneration. After contusive SCI in rats, a thin sheath of omentum was grafted to the injured spinal cord.

resultsOmental graft improved behavior scores significantly from the 3rd to 6th week after injury (6th week, 5.5 ± 0.5 vs. 8.6 ± 1.3,

conclusionsTaken together, the findings of this study indicate that treatment with an omental graft or transposition of an omental flap on an injured spinal cord has a positive effect on nerve protection and tissue preservation in SCI rats. The current data highlight the importance of omentum in clinical applications.

Indexed as

Recovery of FunctionSpinal Cord RegenerationAnimalsNeuroprotectionOmentumRatsSpinal CordSpinal Cord InjuriesSurgical FlapsTransplantation, AutologousTreatment Outcomelamininomentumspinal cord injurytransplantationvascularization

Identifiers

PMID34360697
PMCPMC8347514
OpenAlexW3184595308

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.