Fluorescence Spectroscopic Analysis of ppGpp Binding to cAMP Receptor Protein and Histone-Like Nucleoid Structuring Protein.

Taner Duysak, Thanh Tuyen Tran, Aqeel Rana Afzal, Che-Hun Jung

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.3field-weighted citation impact, top 33% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

A global stress alarmone couples nutrient limitation to suppression of social signaling in bacteria.iScience · 2026
Article
A dual program for CRP-mediated regulation in bacterial alarmone (p)ppGpp.mBio · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Taner DuysakDepartment of Molecular Medicine, Chonnam National University, Gwangju 61186, Korea.ORCID 0000-0001-7603-0458

Thanh Tuyen TranDepartment of Molecular Medicine, Chonnam National University, Gwangju 61186, Korea.ORCID 0000-0002-8903-683X

Aqeel Rana AfzalDepartment of Medical Science, Chonnam National University, Gwangju 61186, Korea.

Che-Hun JungDepartment of Molecular Medicine, Chonnam National University, Gwangju 61186, Korea.

Chonnam National University · KR

Funding

National Research Foundation of Korea NRF-2017R1D1A3B03032721

6 · The paper itself

Abstract

The cyclic AMP receptor protein (CRP) is one of the best-known transcription factors, regulating about 400 genes. The histone-like nucleoid structuring protein (H-NS) is one of the nucleoid-forming proteins and is responsible for DNA packaging and gene repression in prokaryotes. In this study, the binding of ppGpp to CRP and H-NS was determined by fluorescence spectroscopy. CRP from

Indexed as

Bacterial ProteinsBinding SitesCyclic AMPCyclic AMP Receptor ProteinDNA-Binding ProteinsEscherichia coliGuanosine TetraphosphateSpectrometry, FluorescenceBacterial ProteinsCyclic AMPCyclic AMP Receptor ProteinDNA-Binding ProteinsGuanosine TetraphosphateH-NS protein, bacteriaCRPcyclic AMP receptor proteinhistone-like nucleoid structuring proteinH-NSppGpp

Identifiers

PMID34360641

DOI10.3390/ijms22157871

PMCPMC8346002

OpenAlexW3186854492

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.