Evidence map›Paper›PMID 34360611›Full record

ReviewInternational journal of molecular sciences2021

The Role of RNA Secondary Structure in Regulation of Gene Expression in Bacteria.

Agnieszka Chełkowska-Pauszek, Jan Grzegorz Kosiński, Klementyna Marciniak, Marta Wysocka, Kamilla Bąkowska-Żywicka, Marek Żywicki

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 72 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Type IV pilin regulation: a transcriptional overview.Critical reviews in microbiology · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. The RNA-Binding Proteins MCPIP2 and IGF2BP1 Competitively Modulate Breast Tumor Angiogenesis by Antagonizing VEGFA mRNA Stability and Expression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. TheRNA (New York, N.Y.) · 2024
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Agnieszka Chełkowska-PauszekDepartment of Computational Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland.ORCID 0000-0002-4674-3673
Jan Grzegorz KosińskiDepartment of Computational Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland.ORCID 0000-0002-6806-0013
Klementyna MarciniakInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznań, Poland.
Marta WysockaDepartment of Computational Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland.ORCID 0000-0003-1369-1763
Kamilla Bąkowska-ŻywickaInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznań, Poland.ORCID 0000-0002-4129-0038
Marek ŻywickiDepartment of Computational Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland.ORCID 0000-0003-4774-2258
Adam Mickiewicz University in Poznań · PLInstitute of Bioorganic Chemistry, Polish Academy of Sciences · PL

Funding

Narodowe Centrum Nauki UMO-2017/25/B/NZ6/00642
6 · The paper itself

Abstract

Due to the high exposition to changing environmental conditions, bacteria have developed many mechanisms enabling immediate adjustments of gene expression. In many cases, the required speed and plasticity of the response are provided by RNA-dependent regulatory mechanisms. This is possible due to the very high dynamics and flexibility of an RNA structure, which provide the necessary sensitivity and specificity for efficient sensing and transduction of environmental signals. In this review, we will discuss the current knowledge about known bacterial regulatory mechanisms which rely on RNA structure. To better understand the structure-driven modulation of gene expression, we describe the basic theory on RNA structure folding and dynamics. Next, we present examples of multiple mechanisms employed by RNA regulators in the control of bacterial transcription and translation.

Indexed as

Gene Expression Regulation, BacterialNucleic Acid ConformationRNA FoldingBacteriaBacterial ProteinsRNA, BacterialTranscription, GeneticBacterial ProteinsRNA, Bacterialbacterial sRNAsncRNAsregulation of gene expressionriboswitchesRNA structure

Identifiers

PMID34360611
PMCPMC8346122
OpenAlexW3185894165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.