Evidence map›Paper›PMID 34360593›Full record

ArticleInternational journal of molecular sciences2021

Angulin-1 (LSR) Affects Paracellular Water Transport, However Only in Tight Epithelial Cells.

Carlos Ayala-Torres, Susanne M Krug, Rita Rosenthal, Michael Fromm

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Is there a molecular basis for solvent drag in the renal proximal tubule?Pflugers Archiv : European journal of physiology · 2023
    Review
  5. CDT ofToxins · 2023
    Article
  6. Membrane Proteins: Structure, Function and Motion.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Carlos Ayala-TorresClinical Physiology/Nutritional Medicine, Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, 12203 Berlin, Germany.ORCID 0000-0002-2306-6788
Susanne M KrugClinical Physiology/Nutritional Medicine, Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, 12203 Berlin, Germany.ORCID 0000-0002-1293-2484
Rita RosenthalClinical Physiology/Nutritional Medicine, Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, 12203 Berlin, Germany.ORCID 0000-0002-5807-9415
Michael FrommClinical Physiology/Nutritional Medicine, Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, 12203 Berlin, Germany.ORCID 0000-0003-4497-7983
Charité - Universitätsmedizin Berlin · DE

Funding

Deutsche Forschungsgemeinschaft GRK 2318, A3Open Access Publication Fund of the Charité - Universitätsmedizin Berlin
6 · The paper itself

Abstract

Water transport in epithelia occurs transcellularly (aquaporins) and paracellularly (claudin-2, claudin-15). Recently, we showed that downregulated tricellulin, a protein of the tricellular tight junction (tTJ, the site where three epithelial cells meet), increased transepithelial water flux. We now check the hypothesis that another tTJ-associated protein, angulin-1 (

Indexed as

AnimalsBiological TransportDogsEpithelial CellsHT29 CellsHumansMadin Darby Canine Kidney CellsReceptors, LipoproteinTight JunctionsTranscription FactorsWaterLSR protein, humanReceptors, LipoproteinTranscription FactorsWaterangulin-1HT-29/B6 cellsintermediate-tight epitheliumLSRMDCK C7 cellsparacellular water transporttight epitheliumtricellular tight junctiontricellulin

Identifiers

PMID34360593
PMCPMC8346120
OpenAlexW3184430279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.