Evidence map›Paper›PMID 34360592›Full record

ArticleInternational journal of molecular sciences2021

Loss of mGluR5 in D1 Receptor-Expressing Neurons Improves Stress Coping.

Luca Zangrandi, Claudia Schmuckermair, Hussein Ghareh, Federico Castaldi, Regine Heilbronn, Gerald Zernig, Francesco Ferraguti, Arnau Ramos-Prats

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Loss of mGluMolecular psychiatry · 2024
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Luca ZangrandiDepartment of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Claudia SchmuckermairInstitute of Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Hussein GharehDepartment of Psychiatry 1, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Federico CastaldiInstitute of Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Regine HeilbronnDepartment of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.ORCID 0000-0001-6412-3278
Gerald ZernigDepartment of Psychiatry 1, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-1247-1024
Francesco FerragutiInstitute of Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-3843-5857
Arnau Ramos-PratsInstitute of Pharmacology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-4479-803X
Innsbruck Medical University · ATHumboldt-Universität zu Berlin · DE

Funding

Austrian Science Fund W12060-B10Austrian Science Fund W12060-B12Deutsche Forschungsgemeinschaft GO-Bio
6 · The paper itself

Abstract

The metabotropic glutamate receptor type 5 (mGluR5) has been proposed to play a crucial role in the selection and regulation of cognitive, affective, and emotional behaviors. However, the mechanisms by which these receptors mediate these effects remain largely unexplored. Here, we studied the role of mGluR5 located in D1 receptor-expressing (D1) neurons in the manifestation of different behavioral expressions. Mice with conditional knockout (cKO) of mGluR5 in D1 neurons (mGluR5

Indexed as

Adaptation, PsychologicalAnimalsDopamineFemaleMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsReceptor, Metabotropic Glutamate 5Receptors, Dopamine D1Stress, PsychologicalDopamineGrm5 protein, mouseReceptor, Metabotropic Glutamate 5Receptors, Dopamine D1anxietyD1memorymGluR5social behaviorstress

Identifiers

PMID34360592
PMCPMC8346057
OpenAlexW3185541397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.