Evidence map›Paper›PMID 34360575›Full record

ReviewInternational journal of molecular sciences2021

Complexome Profiling: Assembly and Remodeling of Protein Complexes.

Ilka Wittig, Pedro Felipe Malacarne

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  5. Review
  6. Addressing the tissue specificity of U5 snRNP spliceosomopathies.Frontiers in cell and developmental biology · 2025
    Article
  7. Review
  8. Article
  9. Protein assemblies in theFrontiers in plant science · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Aging ofCells · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ilka WittigInstitute for Cardiovascular Physiology, Goethe University, 60590 Frankfurt, Germany.
Pedro Felipe MalacarneInstitute for Cardiovascular Physiology, Goethe University, 60590 Frankfurt, Germany.
Goethe University Frankfurt · DE

Funding

Bundesministerium für Bildung und Forschung German Network for Mitochondrial Disorders (mitoNET, 01GM1906D)Deutsche Forschungsgemeinschaft FOR5046 grant number WI 3728/1-1
6 · The paper itself

Abstract

Many proteins have been found to operate in a complex with various biomolecules such as proteins, nucleic acids, carbohydrates, or lipids. Protein complexes can be transient, stable or dynamic and their association is controlled under variable cellular conditions. Complexome profiling is a recently developed mass spectrometry-based method that combines mild separation techniques, native gel electrophoresis, and density gradient centrifugation with quantitative mass spectrometry to generate inventories of protein assemblies within a cell or subcellular fraction. This review summarizes applications of complexome profiling with respect to assembly ranging from single subunits to large macromolecular complexes, as well as their stability, and remodeling in health and disease.

Indexed as

AnimalsHumansMultiprotein ComplexesProteinsMultiprotein ComplexesProteinsassemblycomplexome profilingdata repositoriesmass spectrometryprotein complexesprotein–protein interactionremodeling

Identifiers

PMID34360575
PMCPMC8346016
OpenAlexW3186342005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.