Evidence map›Paper›PMID 34360573›Full record

ArticleInternational journal of molecular sciences2021

Differential Serotonin Uptake Mechanisms at the Human Maternal-Fetal Interface.

Petra Baković, Maja Kesić, Maja Perić, Ivona Bečeheli, Marina Horvatiček, Meekha George, Lipa Čičin-Šain, Gernot Desoye, Christian Wadsack, Ute Panzenboeck and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Tryptophan's Journey Through Pregnancy: The Role of Serotonin.International journal of tryptophan research : IJTR · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Petra BakovićDepartment of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Maja KesićDepartment of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Maja PerićDepartment of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Ivona BečeheliDepartment of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Marina HorvatičekDepartment of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia.ORCID 0000-0002-0815-3584
Meekha GeorgeOtto Loewi Research Center, Division of Immunology and Pathophysiology, Medical University of Graz, Heinrichstrasse 31a, A-8010 Graz, Austria.ORCID 0000-0003-1537-8770
Lipa Čičin-ŠainDepartment of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia.ORCID 0000-0002-0222-3174
Gernot DesoyeDepartment of Obstetrics and Gynaecology, Medical University of Graz, Auenbruggerplatz 14, A-8036 Graz, Austria.ORCID 0000-0002-5715-3230
Christian WadsackDepartment of Obstetrics and Gynaecology, Medical University of Graz, Auenbruggerplatz 14, A-8036 Graz, Austria.ORCID 0000-0002-5589-8642
Ute PanzenboeckOtto Loewi Research Center, Division of Immunology and Pathophysiology, Medical University of Graz, Heinrichstrasse 31a, A-8010 Graz, Austria.ORCID 0000-0002-0545-6758
Jasminka ŠtefuljDepartment of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia.ORCID 0000-0001-8593-9698
Ruđer Bošković Institute · HRMedical University of Graz · AT

Funding

Austrian Science Fund FWF DOC 31
6 · The paper itself

Abstract

Serotonin (5-HT) plays an extensive role during pregnancy in regulating both the placental physiology and embryonic/fetal development. The uptake of 5-HT into cells is central to the control of local concentrations of 5-HT near its molecular targets. Here, we investigated the mechanisms of 5-HT uptake into human primary placental cells and cord blood platelets, all isolated immediately after birth. Trophoblasts and cord blood platelets showed 5-HT uptake with similar Michaelis constant (

Indexed as

Maternal-Fetal ExchangeFemaleFetusGene Expression RegulationHumansPlacentaPregnancySerotoninSerotonin Plasma Membrane Transport ProteinsSerotonin Receptor AgonistsTrophoblastsSerotoninSerotonin Plasma Membrane Transport ProteinsSerotonin Receptor Agonists5-HTcord bloodfeto-placental endothelial cellsorganic cation transportersplacentaplateletsPMATSERTtrophoblasts

Identifiers

PMID34360573
PMCPMC8346107
OpenAlexW3184414689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.