Evidence map›Paper›PMID 34360546›Full record

ArticleInternational journal of molecular sciences2021

Promyelocytic Leukemia Proteins Regulate Fanconi Anemia Gene Expression.

Anudari Munkhjargal, Myung-Jin Kim, Da-Yeon Kim, Young-Jun Jeon, Young-Hoon Kee, Lark-Kyun Kim, Yong-Hwan Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Molecular Target and Action Mechanism of Anti-Cancer Agents.International journal of molecular sciences · 2023
    Article
  2. Focal Point of Fanconi Anemia Signaling.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Anudari MunkhjargalDepartment of Biological Sciences, Research Institute of Women's Health, College of Natural Sciences, Sookmyung Women's University, Seoul 04310, Korea.
Myung-Jin KimDepartment of Biological Sciences, Research Institute of Women's Health, College of Natural Sciences, Sookmyung Women's University, Seoul 04310, Korea.ORCID 0000-0002-7992-4585
Da-Yeon KimDepartment of Biological Sciences, Research Institute of Women's Health, College of Natural Sciences, Sookmyung Women's University, Seoul 04310, Korea.ORCID 0000-0003-1461-572X
Young-Jun JeonDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea.ORCID 0000-0002-5998-9605
Young-Hoon KeeDepartment of New Biology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Korea.
Lark-Kyun KimSeverance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06230, Korea.ORCID 0000-0001-5983-4470
Yong-Hwan KimDepartment of Biological Sciences, Research Institute of Women's Health, College of Natural Sciences, Sookmyung Women's University, Seoul 04310, Korea.ORCID 0000-0001-8574-4938
Sookmyung Women's University · KRDaegu Gyeongbuk Institute of Science and Technology · KRSungkyunkwan University · KRYonsei University · KR

Funding

National Research Foundation funded by the Ministry of Science, ICT & Future Planning of the Korean government NRF-2014M3C9A2064688National Research Foundation funded by the Ministry of Science, ICT & Future Planning of the Korean government NRF-2016R1A5A1011974National Research Foundation funded by the Ministry of Science, ICT & Future Planning of the Korean government NRF-2019R1A2C2089746National Research Foundation funded by the Ministry of Science, ICT & Future Planning of the Korean government NRF-2020R1I1A1A01061661
6 · The paper itself

Abstract

Promyelocytic leukemia (PML) protein is the core component of subnuclear structures called PML nuclear bodies that are known to play important roles in cell survival, DNA damage responses, and DNA repair. Fanconi anemia (FA) proteins are required for repairing interstrand DNA crosslinks (ICLs). Here we report a novel role of PML proteins, regulating the ICL repair pathway. We found that depletion of the PML protein led to the significant reduction of damage-induced

Indexed as

Gene Expression RegulationCheckpoint Kinase 1DNA DamageDNA RepairFanconi AnemiaFanconi Anemia Complementation Group A ProteinFanconi Anemia Complementation Group D2 ProteinFanconi Anemia Complementation Group G ProteinHeLa CellsHumansPhosphorylationUbiquitinationCheckpoint Kinase 1CHEK1 protein, humanFANCA protein, humanFANCD2 protein, humanFANCG protein, humanFanconi Anemia Complementation Group A ProteinFanconi Anemia Complementation Group D2 ProteinFanconi Anemia Complementation Group G ProteinCHK1 inhibitorsFanconi anemiainterstrand DNA crosslinkPML nuclear body

Identifiers

PMID34360546
PMCPMC8346011
OpenAlexW3186377674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.