Evidence map›Paper›PMID 34360530›Full record

ReviewInternational journal of molecular sciences2021

Exosomes as New Biomarkers and Drug Delivery Tools for the Prevention and Treatment of Various Diseases: Current Perspectives.

Qi Liu, Shiying Li, Amandine Dupuy, Hoa le Mai, Nicolas Sailliet, Cédric Logé, J-Michel H Robert, Sophie Brouard

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Exosome Proteomics of SOD1Annals of clinical and translational neurology · 2026
    Article
  6. Migrasomes: A Novel Target for Cancer Treatment.Current cancer drug targets · 2026
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Extracellular Vesicles for Disease Treatment.International journal of nanomedicine · 2025
    Review
  16. Application of engineered exosomes in tumor therapy.American journal of translational research · 2025
    Review
  17. Exosomes fromInternational journal of molecular sciences · 2024
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qi LiuDepartment of Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Shiying LiDepartment of Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Amandine DupuyUnite Mixte de Recherche 1064, Centre de Recherche en Transplantation et Immunologie, Inserm, CHU Nantes, Université de Nantes, ITUN, F-44000 Nantes, France.
Hoa le MaiUnite Mixte de Recherche 1064, Centre de Recherche en Transplantation et Immunologie, Inserm, CHU Nantes, Université de Nantes, ITUN, F-44000 Nantes, France.
Nicolas SaillietUnite Mixte de Recherche 1064, Centre de Recherche en Transplantation et Immunologie, Inserm, CHU Nantes, Université de Nantes, ITUN, F-44000 Nantes, France.ORCID 0000-0002-0232-1663
Cédric LogéInstitut de Recherche en Santé 2, 22, Cibles et Médicaments du Cancer et de l'Immunité IICiMed-AE1155, Nantes Atlantique Universités, Université de Nantes, Boulevard Bénoni-Goullin, F-44000 Nantes, France.ORCID 0000-0001-5113-6547
J-Michel H RobertInstitut de Recherche en Santé 2, 22, Cibles et Médicaments du Cancer et de l'Immunité IICiMed-AE1155, Nantes Atlantique Universités, Université de Nantes, Boulevard Bénoni-Goullin, F-44000 Nantes, France.
Sophie BrouardUnite Mixte de Recherche 1064, Centre de Recherche en Transplantation et Immunologie, Inserm, CHU Nantes, Université de Nantes, ITUN, F-44000 Nantes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are nano-sized vesicles secreted by most cells that contain a variety of biological molecules, such as lipids, proteins and nucleic acids. They have been recognized as important mediators for long-distance cell-to-cell communication and are involved in a variety of biological processes. Exosomes have unique advantages, positioning them as highly effective drug delivery tools and providing a distinct means of delivering various therapeutic agents to target cells. In addition, as a new clinical diagnostic biomarker, exosomes play an important role in many aspects of human health and disease, including endocrinology, inflammation, cancer, and cardiovascular disease. In this review, we summarize the development of exosome-based drug delivery tools and the validation of novel biomarkers, and illustrate the role of exosomes as therapeutic targets in the prevention and treatment of various diseases.

Indexed as

Drug Delivery SystemsBiomarkersCardiovascular DiseasesExosomesHumansInflammationNeoplasmsPharmaceutical PreparationsBiomarkersPharmaceutical Preparationsbiomarkersdiseasesdrug delivery toolsexosomestherapeutic target

Identifiers

PMID34360530
PMCPMC8346134

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.