Evidence map›Paper›PMID 34360264›Full record

ArticleInternational journal of environmental research and public health2021

Longitudinal Associations between the Neighborhood Built Environment and Cognition in US Older Adults: The Multi-Ethnic Study of Atherosclerosis.

Lilah M Besser, Lun-Ching Chang, Jana A Hirsch, Daniel A Rodriguez, John Renne, Stephen R Rapp, Annette L Fitzpatrick, Susan R Heckbert, Joel D Kaufman, Timothy M Hughes

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Mediating Role of Physical Activity on Associations Between Neighborhood Environments and Mental Health in China.Journal of urban health : bulletin of the New York Academy of Medicine · 2025
    Article
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  9. Review
  10. Article
  11. Article
  12. Article
  13. Rural Roads to Cognitive Resilience (RRR): A prospective cohort study protocol.medRxiv : the preprint server for health sciences · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Global rural health disparities in Alzheimer's disease and related dementias: State of the science.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Review
  18. Big data from small animals: integrating multi-level environmental data into the Dog Aging Project.Revue scientifique et technique (International Office of Epizootics) · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lilah M BesserDepartment of Urban and Regional Planning and Institute for Human Health and Disease Intervention, Florida Atlantic University, Boca Raton, FL 33431, USA.ORCID 0000-0001-9945-0877
Lun-Ching ChangDepartment of Mathematical Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA.ORCID 0000-0002-8039-5350
Jana A HirschUrban Health Collaborative and Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA 19104, USA.ORCID 0000-0003-3355-5558
Daniel A RodriguezDepartment of City and Regional Planning, Institute for Transportation Studies, University of California Berkeley, Berkeley, CA 94720, USA.
John RenneDepartment of Urban and Regional Planning, Florida Atlantic University, Boca Raton, FL 33431, USA.
Stephen R RappDepartment of Psychiatry & Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.
Annette L FitzpatrickDepartments of Family Medicine, Epidemiology, and Global Health, University of Washington, Seattle, WA 98105, USA.
Susan R HeckbertCardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA 98105, USA.
Joel D KaufmanDepartments of Environmental and Occupational Health Sciences, Medicine, and Epidemiology, University of Washington, Seattle, WA 98105, USA.ORCID 0000-0003-4174-9037
Timothy M HughesDepartment of Internal Medicine, Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.ORCID 0000-0002-2919-7199

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI ALI SHOJAIE · 1995 to 2026
$42.5M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BATEMAN, JAMES R., CRAFT, SUZANNE · 2016 to 2020
$12.2M
CARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
$8.4M
Longitudinal Neighborhood Determinants of ADRD Progression within a Multi-Site CohortR01AG072634 · NIA · DREXEL UNIVERSITY · PI Jana Ariel Hirsch · 2021 to 2026
$6.1M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Neighborhoods and CVD Risk in a Multiethnic Cohort (RMI)R01HL071759 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ ROUX, ANA VICTORIA, LISABETH, LYNDA D · 2003 to 2013
$4.8M
TO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5M
CLC NIH HHS 75N90020D00002CLC NIH HHS 75N90020D00003NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL071759NIAID NIH HHS 75N93020D00002NIA NIH HHS K01 AG063895NIA NIH HHS K01AG063895NIA NIH HHS P30 AG049638NIA NIH HHS R01 AG072634NIDA NIH HHS 75N95020D00002NIDA NIH HHS 75N95020D00003NIDA NIH HHS 75N95020D00004NIDA NIH HHS 75N95020D00005NIDA NIH HHS 75N95020D00007NIEHS NIH HHS 75N96020D00002NIEHS NIH HHS 75N96020D00003NIEHS NIH HHS P30 ES007033NIH HHS 75N98020D00007ORFDO NIH HHS 75N99020D00002ORFDO NIH HHS 75N99020D00003ORFDO NIH HHS 75N99020D00004ORFDO NIH HHS 75N99020D00005ORFDO NIH HHS 75N99020D00006ORFDO NIH HHS 75N99020D00007
6 · The paper itself

Abstract

Few studies have examined associations between neighborhood built environments (BE) and longitudinally measured cognition. We examined whether four BE characteristics were associated with six-year change in global cognition and processing speed. We obtained data on 1816 participants without dementia from the Multi-Ethnic Study of Atherosclerosis. BE measures included social destination density, walking destination density, proportion of land dedicated to retail, and network ratio (street connectivity). Global cognition was measured with the Cognitive Abilities Screening Instrument (CASI) and processing speed with the Digit Symbol Coding test (DSC). Multivariable random intercept logistic models tested associations between neighborhood BE at 2010-2012 and maintained/improved cognition (versus decline) from 2010-2018, and mediation by minutes of physical activity (PA)/week. The sample was an average of 67 years old (standard deviation = 8.2) (first cognitive measurement) and racially/ethnically diverse (29% African American, 11% Chinese, 17% Hispanic, 44% White). Compared to individuals with no walking destinations in the 1-mile surrounding their residence, those with 716 walking destinations (maximum observed) were 1.24 times more likely to have maintain/improved DSC score (Odds ratio: 1.24; 95% confidence interval: 1.03-1.45). No other associations were observed between BE and cognition, and PA minutes/week did not mediate the association between walking destination density and DSC change. This study provides limited evidence for an association between greater neighborhood walking destinations and maintained/improved processing speed in older age and no evidence for associations between the other BE characteristics and cognition. Future studies with finer grained BE and cognitive measures and longer-term follow up may be required.

Indexed as

AtherosclerosisBuilt EnvironmentAgedCognitionCross-Sectional StudiesEnvironment DesignHumansResidence CharacteristicsWalkingAlzheimer diseasebuilt environmentcity planningcognitionland useolder adultpreventive medicinepublic healthresidence characteristicswalking destination

Identifiers

PMID34360264
PMCPMC8345405

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.