Evidence map›Paper›PMID 34359992›Full record

ArticleCells2021

Cytokine-Mediated Regulation of ARG1 in Macrophages and Its Impact on the Control of

Natascha Brigo, Christa Pfeifhofer-Obermair, Piotr Tymoszuk, Egon Demetz, Sabine Engl, Marina Barros-Pinkelnig, Stefanie Dichtl, Christine Fischer, Lara Valente De Souza, Verena Petzer and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Purslane (Preventive nutrition and food science · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. ConcurrentmSphere · 2024
    Article
  7. Article
  8. Macrophage variants in laboratory research: most are well done, but some are RAW.Frontiers in cellular and infection microbiology · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Cells · 2022
    Article
  14. Article
  15. Article
  16. Frontiers in microbiology · 2022
    Article
  17. Article
  18. Dietary Iron Overload andAntioxidants (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Natascha BrigoDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Christa Pfeifhofer-ObermairDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Piotr TymoszukDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.ORCID 0000-0002-0398-6034
Egon DemetzDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Sabine EnglDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Marina Barros-PinkelnigDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Stefanie DichtlDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Christine FischerDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Lara Valente De SouzaDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.ORCID 0000-0002-0370-2791
Verena PetzerDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Laura von RaffayDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Richard HilbeDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Sylvia BergerDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Markus SeifertDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Ulrike SchleicherMikrobiologisches Institut-Klinische Mikrobiologie, Immunologie, und Hygiene, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, Wasserturmstraße 3/5, 91054 Erlangen, Germany.
Christian BogdanMikrobiologisches Institut-Klinische Mikrobiologie, Immunologie, und Hygiene, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, Wasserturmstraße 3/5, 91054 Erlangen, Germany.
Günter WeissDepartment of Internal Medicine II, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.ORCID 0000-0003-0709-2158
Innsbruck Medical University · ATFriedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

Austrian Science Fund FWF I 3321Christian Doppler SocietyDeutsche Forschungsgemeinschaft C04FWF-Doctoral Program-HOROS W1253INFECT-ERA grant of the European Union; BMBF BMBF 031L0126INFECT-ERA grant of the European Union ; FWF FWF-I03321
6 · The paper itself

Abstract

Arginase 1 (ARG1) is a cytosolic enzyme that cleaves L-arginine, the substrate of inducible nitric oxide synthase (iNOS), and thereby impairs the control of various intracellular pathogens. Herein, we investigated the role of ARG1 during infection with

Indexed as

AnimalsArginaseBone Marrow CellsCation Transport ProteinsCytokinesIntegrasesInterleukin-4MacrophagesMiceMice, Inbred C57BLMice, TransgenicNatural Resistance-associated Macrophage Protein 1PyrrolidinesSalmonella Infections, AnimalSalmonella typhimuriumUp-RegulationArg1 protein, mouseArginaseCation Transport ProteinsCB-1158Cre recombinaseCytokinesIntegrasesInterleukin-4Natural Resistance-associated Macrophage Protein 1Pyrrolidinesarginase 1inducible nitric oxide synthaseintracellular bacteriamacrophagesSalmonella enterica serovar Typhimurium

Identifiers

PMID34359992
PMCPMC8307077
OpenAlexW3185590730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.