Evidence map›Paper›PMID 34359957›Full record

ArticleCells2021

MiRNA Profiling in Plasma and Placenta of SARS-CoV-2-Infected Pregnant Women.

Irma Saulle, Micaela Garziano, Claudio Fenizia, Gioia Cappelletti, Francesca Parisi, Mario Clerici, Irene Cetin, Valeria Savasi, Mara Biasin

Abstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  15. Article
  16. Review
  17. miRNA expression in COVID-19.Gene reports · 2022
    Review
  18. Review
  19. Review
  20. Therapeutic prospects of ceRNAs in COVID-19.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Irma SaulleDepartment of Biomedical and Clinical Sciences, University of Milan, 20157 Milan, Italy.ORCID 0000-0002-8600-2503
Micaela GarzianoDepartment of Biomedical and Clinical Sciences, University of Milan, 20157 Milan, Italy.
Claudio FeniziaDepartment of Biomedical and Clinical Sciences, University of Milan, 20157 Milan, Italy.ORCID 0000-0003-0735-8331
Gioia CappellettiDepartment of Biomedical and Clinical Sciences, University of Milan, 20157 Milan, Italy.ORCID 0000-0002-2932-2391
Francesca ParisiUnit of Obstetrics and Gynecology, ASST Fatebenefratelli-Sacco, Department of Biological and Clinical Sciences L. Sacco, University of Milan, 20157 Milan, Italy.ORCID 0000-0003-2017-7869
Mario ClericiDepartment of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy.ORCID 0000-0001-5920-6191
Irene CetinDepartment of Biomedical and Clinical Sciences, University of Milan, 20157 Milan, Italy.ORCID 0000-0002-9217-3034
Valeria SavasiDepartment of Biomedical and Clinical Sciences, University of Milan, 20157 Milan, Italy.ORCID 0000-0002-1476-7689
Mara BiasinDepartment of Biomedical and Clinical Sciences, University of Milan, 20157 Milan, Italy.ORCID 0000-0003-3671-4235

Funding

Bando Regione Lombardia DG Welfare RL_DG-WEL20MBIAS_01CARIPLO - EXTRABANDO E PROGETTI TERRITORIALI CAR_EXT20MBIAS_01
6 · The paper itself

Abstract

MicroRNAs are gene expression regulators associated with several human pathologies, including those generated by viral infections. Their role in SARS-CoV-2 infection and COVID-19 has been investigated and reviewed in many informative studies; however, a thorough miRNA outline in SARS-CoV-2-infected pregnant women (SIPW), at both systemic and placental levels, is missing. To fill this gap, blood and placenta biopsies collected at delivery from 15 asymptomatic SIPW were immediately analysed for: miRNA expression (

Indexed as

AdultCOVID-19FemaleHumansMicroRNAsPlacentaPregnancyPregnancy Complications, InfectiousSARS-CoV-2TranscriptomeYoung AdultMicroRNAsimmune responseMicroRNApregnant womenSARS-CoV-2

Identifiers

PMID34359957
PMCPMC8305278

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.