Evidence map›Paper›PMID 34359918›Full record

ArticleCells2021

RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells.

Eda Demirel, Caroline Arnold, Jaspal Garg, Marius Andreas Jäger, Carsten Sticht, Rui Li, Hanna Kuk, Nina Wettschureck, Markus Hecker, Thomas Korff

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Eda DemirelDepartment of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.
Caroline ArnoldDepartment of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.
Jaspal GargDepartment of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.
Marius Andreas JägerDepartment of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0003-0797-2673
Carsten StichtNGS Core Facility, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Rui LiDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.
Hanna KukThe Ottawa Department of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Nina WettschureckDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.
Markus HeckerDepartment of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.
Thomas KorffDepartment of Cardiovascular Physiology, Institute of Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.
Heidelberg University · DEMax Planck Institute for Heart and Lung Research · DEUniversity of Ottawa · CA

Funding

Deutsche Forschungsgemeinschaft 394046768-SFB 1366-B5
6 · The paper itself

Abstract

The regulator of G-protein signaling 5 (RGS5) acts as an inhibitor of Gα

Indexed as

Cell Cycle CheckpointsAnimalsBlood PressureCalciumCell MovementCell ProliferationDiastoleGTP-Binding Protein alpha Subunits, Gi-GoHumansMiceMice, Inbred C57BLMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Muscle, Smooth, VascularMyocytes, Smooth MusclePhosphorylationCalciumGTP-Binding Protein alpha Subunits, Gi-GoMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Rgs5 protein, mouseRGS ProteinsrhoA GTP-Binding Proteinblood pressureERK1/2G-protein signalingRGS proteinsVSMC phenotype

Identifiers

PMID34359918
PMCPMC8306326
OpenAlexW3177712224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.