Evidence map›Paper›PMID 34359901›Full record

ArticleCells2021

Group V Phospholipase A

Yu Maw Htwe, Huashan Wang, Patrick Belvitch, Lucille Meliton, Mounica Bandela, Eleftheria Letsiou, Steven M Dudek

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Staphylococcus aureus-vascular endothelium interactions: Mechanisms and therapeutic opportunities.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Mechanisms of lung endothelial cell injury and survival in pulmonary arterial hypertension.American journal of physiology. Lung cellular and molecular physiology · 2024
    Review
  7. Epigenetic mechanisms mediate cytochrome P450 1A1 expression and lung endothelial injury caused by MRSA in vitro and in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Cortactin in Lung Cell Function and Disease.International journal of molecular sciences · 2022
    Review
  14. Article
  15. MRSA-induced endothelial permeability and acute lung injury are attenuated by FTY720 S-phosphonate.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yu Maw HtweDivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Huashan WangDivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Patrick BelvitchDivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Lucille MelitonDivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Mounica BandelaDivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Eleftheria LetsiouDivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Steven M DudekDivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
University of Illinois Chicago · US

Funding

Pulmonary and Critical Care Post-Doctoral Research Training ProgramT32HL082547 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FINN, PATRICIA W · 2007 to 2017
$2.7M
Group V Phospholipase A2 Mediates Acute Lung InjuryR01HL133059 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEK, STEVEN M · 2017 to 2020
$1.6M
Protein Regulation and Cytoskeletal Dynamics of Pulmonary Endothelial Barrier FunctionK08HL135318 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BELVITCH, PATRICK · 2017 to 2021
$975k
Hypothermia for Cardiac Arrest: Optimizing Akt-Nitric Oxide Synthase SignalingK08HL091184 · NHLBI · UNIVERSITY OF CHICAGO · PI BEISER, DAVID GUSTAV · 2008 to 2012
$621k
American Heart Association 14GRNT20460186NHLBI NIH HHS K08 HL135318NHLBI NIH HHS R01 HL133059NIH HHS T32 HL082547
6 · The paper itself

Abstract

Lung endothelial dysfunction is a key feature of acute lung injury (ALI) and clinical acute respiratory distress syndrome (ARDS). Previous studies have identified the lipid-generating enzyme, group V phospholipase A2 (gVPLA

Indexed as

Acute Lung InjuryAnimalsCell Membrane PermeabilityEndothelial CellsIndolesLungMethicillin-Resistant Staphylococcus aureusMiceMice, KnockoutModels, BiologicalPhospholipases A2IndolesLY 311727Phospholipases A2ALIARDSbacterial infectionendotheliumgVPLA2intravital microscopyMRSAPLA2G5secretory phospholipase A2sPLA2-VUSA300

Identifiers

PMID34359901
PMCPMC8304832
OpenAlexW3179448884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.