Evidence map›Paper›PMID 34359889›Full record

ArticleCells2021

Contribution of Adventitia-Derived Stem and Progenitor Cells to New Vessel Formation in Tumors.

Berin Upcin, Erik Henke, Florian Kleefeldt, Helene Hoffmann, Andreas Rosenwald, Ster Irmak-Sav, Huseyin Bertal Aktas, Uwe Rückschloß, Süleyman Ergün

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Berin UpcinInstitute of Anatomy and Cell Biology, Julius-Maximilians-University, 97070 Würzburg, Germany.ORCID 0000-0003-4853-9358
Erik HenkeInstitute of Anatomy and Cell Biology, Julius-Maximilians-University, 97070 Würzburg, Germany.ORCID 0000-0003-2380-2682
Florian KleefeldtInstitute of Anatomy and Cell Biology, Julius-Maximilians-University, 97070 Würzburg, Germany.
Helene HoffmannInstitute of Anatomy and Cell Biology, Julius-Maximilians-University, 97070 Würzburg, Germany.
Andreas RosenwaldInstitute of Pathology, Julius-Maximilians-University, 97070 Würzburg, Germany.
Ster Irmak-SavFaculty of Health Sciences, İstanbul Bilgi University, 34060 Istanbul, Turkey.ORCID 0000-0002-0226-2560
Huseyin Bertal AktasDepartment of Medicine, Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Uwe RückschloßInstitute of Anatomy and Cell Biology, Julius-Maximilians-University, 97070 Würzburg, Germany.
Süleyman ErgünInstitute of Anatomy and Cell Biology, Julius-Maximilians-University, 97070 Würzburg, Germany.
University of Würzburg · DEBrigham and Women's Hospital · USIstanbul Bilgi University · TR

Funding

Deutsche Forschungsgemeinschaft 374031971-TRR 240
6 · The paper itself

Abstract

Blocking tumor vascularization has not yet come to fruition to the extent it was hoped for, as angiogenesis inhibitors have shown only partial success in the clinic. We hypothesized that under-appreciated vascular wall-resident stem and progenitor cells (VW-SPCs) might be involved in tumor vascularization and influence effectiveness of anti-angiogenic therapy. Indeed, in patient samples, we observed that vascular adventitia-resident CD34

Indexed as

AdventitiaAnimalsAntigens, CD34AortaCapillariesHumansMiceModels, BiologicalNeoplasmsNeovascularization, PathologicNeovascularization, PhysiologicRatsReceptors, Vascular Endothelial Growth FactorStem CellsAntigens, CD34Receptors, Vascular Endothelial Growth Factoraortic adventitiatumor spheroidstumor-vessel wall-interface modelvascularization modelvascular wall stem and progenitor cellsvasculogenesis

Identifiers

PMID34359889
PMCPMC8304670
OpenAlexW3181059897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.