Evidence map›Paper›PMID 34359884›Full record

ReviewCells2021

Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer.

Macus Hao-Ran Bao, Carmen Chak-Lui Wong

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed, 3 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

208 citing papers in PubMed, 3 syntheses or guidelines pooled it, 298 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Observational
  6. Review
  7. Article
  8. Article
  9. Article
  10. Understanding how hypoxia contributes to liver cancer stem cells maintenance.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Trefoil Factor-3 Is a Hypoxia-Triggered Pro-Tumorigenic Factor in Hepatoblastoma.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Macus Hao-Ran BaoDepartment of Pathology, The University of Hong Kong, Hong Kong, China.
Carmen Chak-Lui WongDepartment of Pathology, The University of Hong Kong, Hong Kong, China.
University of Hong Kong · HK

Funding

Program for Guangdong Introducing Innovative and Entrepreneurial Teams 2019BT02Y198
6 · The paper itself

Abstract

Hypoxia, low oxygen (O

Indexed as

Antibodies, Monoclonal, HumanizedAntineoplastic AgentsCarcinoma, HepatocellularCellular ReprogrammingDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitImmune Checkpoint InhibitorsLiver NeoplasmsMetabolic Networks and PathwaysNivolumabProtein Kinase InhibitorsPyruvate Dehydrogenase Acetyl-Transferring KinaseSorafenibAntibodies, Monoclonal, HumanizedAntineoplastic AgentsHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitImmune Checkpoint InhibitorsNivolumabPDK1 protein, humanpembrolizumabProtein Kinase InhibitorsPyruvate Dehydrogenase Acetyl-Transferring KinaseSorafenibdrug resistancehypoxiaICIsliver cancermetabolic reprogrammingmetabolismTKIs

Identifiers

PMID34359884
PMCPMC8304710
OpenAlexW3178403391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.