Evidence map›Paper›PMID 34359880›Full record

ArticleCells2021

Changes in Cerebrospinal Fluid Balance of TNF and TNF Receptors in Naïve Multiple Sclerosis Patients: Early Involvement in Compartmentalised Intrathecal Inflammation.

Roberta Magliozzi, Francesco Pezzini, Mairi Pucci, Stefania Rossi, Francesco Facchiano, Damiano Marastoni, Martina Montagnana, Giuseppe Lippi, Richard Reynolds, Massimiliano Calabrese

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  9. Article
  10. Review
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  12. Article
  13. The Possible Role of Neural Cell Apoptosis in Multiple Sclerosis.International journal of molecular sciences · 2022
    Review
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Roberta MagliozziDepartment of Neuroscience, Biomedicine and Movement Science, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-8284-7763
Francesco PezziniDepartment of Neuroscience, Biomedicine and Movement Science, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-1590-4558
Mairi PucciDepartment of Neuroscience, Biomedicine and Movement Science, University of Verona, 37134 Verona, Italy.
Stefania RossiDepartment of Oncology and Molecular Medicine, Higher Institute of Health Care, 00161 Rome, Italy.ORCID 0000-0002-8854-7072
Francesco FacchianoDepartment of Oncology and Molecular Medicine, Higher Institute of Health Care, 00161 Rome, Italy.
Damiano MarastoniDepartment of Neuroscience, Biomedicine and Movement Science, University of Verona, 37134 Verona, Italy.
Martina MontagnanaDepartment of Neuroscience, Biomedicine and Movement Science, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-8999-0001
Giuseppe LippiDepartment of Neuroscience, Biomedicine and Movement Science, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-9523-9054
Richard ReynoldsDepartment of Brain Sciences, Department of Medicine, Imperial College London, London W12 0NN, UK.ORCID 0000-0003-4622-4694
Massimiliano CalabreseDepartment of Neuroscience, Biomedicine and Movement Science, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-3362-7403
University of Verona · ITImperial College London · GB

Funding

Italian MS Foundation (FISM) FISM 16/17/F14
6 · The paper itself

Abstract

An imbalance of TNF signalling in the inflammatory milieu generated by meningeal immune cell infiltrates in the subarachnoid space in multiple sclerosis (MS), and its animal model may lead to increased cortical pathology. In order to explore whether this feature may be present from the early stages of MS and may be associated with the clinical outcome, the protein levels of TNF, sTNF-R1 and sTNF-R2 were assayed in CSF collected from 122 treatment-naïve MS patients and 36 subjects with other neurological conditions at diagnosis. Potential correlations with other CSF cytokines/chemokines and with clinical and imaging parameters at diagnosis (T0) and after 2 years of follow-up (T24) were evaluated. Significantly increased levels of TNF (fold change: 7.739;

Indexed as

Adaptive ImmunityAdultAntigens, CDAntigens, Differentiation, MyelomonocyticB-LymphocytesCase-Control StudiesCD163 AntigenCerebral CortexChemokine CXCL13Chitinase-3-Like Protein 1C-Reactive ProteinCytokine TWEAKEarly DiagnosisFemaleGene Expression RegulationHumansAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenChemokine CXCL13CHI3L1 protein, humanChitinase-3-Like Protein 1C-Reactive ProteinCXCL13 protein, humanCytokine TWEAKinterleukin-35, humanInterleukinsOsteopontinPentraxinsReceptors, Cell SurfaceReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IISerum Amyloid P-ComponentSPP1 protein, humanTNFRSF1A protein, humanTNFSF12 protein, humanTNFSF14 protein, humanTumor Necrosis Factor-alphaTumor Necrosis Factor Ligand Superfamily Member 14cerebrospinal fluidinflammationmultiple sclerosispathway analysisTNF

Identifiers

PMID34359880
PMCPMC8303813
OpenAlexW3179322089

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.