Evidence map›Paper›PMID 34359866›Full record

ArticleCells2021

A Bimodal Fluorescence-Raman Probe for Cellular Imaging.

Jiarun Lin, Marcus E Graziotto, Peter A Lay, Elizabeth J New

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  6. Article
  7. Analytical Techniques for Single-Cell Biochemical Assays of Lipids.Annual review of biomedical engineering · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jiarun LinSchool of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Marcus E GraziottoSchool of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-8157-2021
Peter A LaySchool of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Elizabeth J NewSchool of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-2310-254X
The University of Sydney · AU

Funding

Australian Research Council DP160104172Australian Research Council DP180101353
6 · The paper itself

Abstract

Biochemical changes in specific organelles underpin cellular function, and studying these changes is crucial to understand health and disease. Fluorescent probes have become important biosensing and imaging tools as they can be targeted to specific organelles and can detect changes in their chemical environment. However, the sensing capacity of fluorescent probes is highly specific and is often limited to a single analyte of interest. A novel approach to imaging organelles is to combine fluorescent sensors with vibrational spectroscopic imaging techniques; the latter provides a comprehensive map of the relative biochemical distributions throughout the cell to gain a more complete picture of the biochemistry of organelles. We have developed

Indexed as

Optical ImagingSpectrum Analysis, Raman3T3-L1 CellsAnimalsCell SurvivalFluorescenceFluorescent DyesMiceNaphthalimidesPrincipal Component AnalysisFluorescent DyesNaphthalimidesfluorescent probelipid dropletsmultimodal imagingRaman spectroscopy

Identifiers

PMID34359866
PMCPMC8303253
OpenAlexW3181272586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.