Evidence map›Paper›PMID 34359864›Full record

ArticleCells2021

Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models.

Dinesh Kumar Verma, Bo Am Seo, Anurupa Ghosh, Shi-Xun Ma, Karina Hernandez-Quijada, Julie K Andersen, Han Seok Ko, Yong-Hwan Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 79 citations in OpenAlex.

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  19. Article
  20. A hypothesis explaining Alzheimer's disease, Parkinson's disease, and dementia with Lewy bodies overlap.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Dinesh Kumar VermaNeuroscience Program, Department of Biological Sciences, Delaware State University, Dover, DE 19901, USA.ORCID 0000-0002-4235-9973
Bo Am SeoDepartment of Neurology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.
Anurupa GhoshNeuroscience Program, Department of Biological Sciences, Delaware State University, Dover, DE 19901, USA.
Shi-Xun MaDepartment of Neurology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.
Karina Hernandez-QuijadaNeuroscience Program, Department of Biological Sciences, Delaware State University, Dover, DE 19901, USA.
Julie K AndersenBuck Institute for Research on Aging, Novato, CA 94945, USA.
Han Seok KoDepartment of Neurology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.
Yong-Hwan KimNeuroscience Program, Department of Biological Sciences, Delaware State University, Dover, DE 19901, USA.ORCID 0000-0001-7224-0503
Delaware State University · USJohns Hopkins University · USBuck Institute for Research on Aging · US

Funding

Updated confocal microscope in the Imaging Core facility to support biomedical researchP20GM103653 · NIGMS · DELAWARE STATE UNIVERSITY · PI HARRINGTON, MELISSA A · 2012 to 2022
$22.7M
The role of NOD2/RIPK2 signaling in the pathogenesis of Parkinson's DiseaseR01NS107404 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KO, HANSEOK · 2018 to 2022
$1.8M
A Summer Undergraduate Research Program in Neuroscience at an HBCUR25NS095371 · NINDS · DELAWARE STATE UNIVERSITY · PI HARRINGTON, MELISSA A · 2015 to 2025
$1.1M
NIGMS NIH HHS P20 GM103653NIH HHS 5P20GM103653NIH HHS R01NS107404NINDS NIH HHS R01 NS107404NINDS NIH HHS R25 NS095371
6 · The paper itself

Abstract

Emerging evidence indicates that cellular senescence could be a critical inducing factor for aging-associated neurodegenerative disorders. However, the involvement of cellular senescence remains unclear in Parkinson's disease (PD). To determine this, we assessed the effects of α-synuclein preformed fibrils (α-syn PFF) or 1-methyl-4-phenylpyridinium (MPP

Indexed as

Cellular Senescence1-Methyl-4-phenylpyridiniumalpha-SynucleinAnimalsAstrocytesBiomarkersBrainCell LineCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Disease Models, AnimalDopaminergic NeuronsFemaleGlial Fibrillary Acidic ProteinHMGB1 ProteinHomeodomain Proteins1-Methyl-4-phenylpyridiniumalpha-SynucleinBiomarkersCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Glial Fibrillary Acidic ProteinHMGB1 ProteinHomeodomain ProteinsLamin Type BSATB1 protein, ratalpha-synuclein preformed fibrilscellular senescenceHMGB1Lamin B1microglia activationp21reactive astrocytesSATB1

Identifiers

PMID34359864
PMCPMC8304385
OpenAlexW3179015401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.