Evidence map›Paper›PMID 34359845›Full record

ArticleCells2021

Function and Biomarkers of the Blood-Brain Barrier in a Neonatal Germinal Matrix Haemorrhage Model.

Erik Axel Andersson, Eridan Rocha-Ferreira, Henrik Hagberg, Carina Mallard, Carl Joakim Ek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Temporal brain transcriptome analysis reveals key pathological events after germinal matrix hemorrhage in neonatal rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Erik Axel AnderssonInstitute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 11, 413 90 Gothenburg, Sweden.ORCID 0000-0002-7165-3709
Eridan Rocha-FerreiraInstitute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 90 Gothenburg, Sweden.ORCID 0000-0002-9342-4691
Henrik HagbergInstitute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 90 Gothenburg, Sweden.
Carina MallardInstitute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 11, 413 90 Gothenburg, Sweden.ORCID 0000-0001-8953-919X
Carl Joakim EkInstitute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 11, 413 90 Gothenburg, Sweden.
University of Gothenburg · SE

Funding

Åke Wibergs Foundation M19-0660Brain Foundation 2015-0004ERA-NET Contract: 0755101EU Contract: 874721 Horizon 2020Public Health Service at the Sahlgrenska University Hospital ALFGBG-722491Swedish Brain Foundation FO2019-0270Swedish Governmental Grant to Researchers at University Hospitals ALFGBG-718591Swedish Research Council VR-2017-01409The Hasselblad Foundation 2020-2021The Swedish Medical Research Council VR (2019-01320)
6 · The paper itself

Abstract

Germinal matrix haemorrhage (GMH), caused by rupturing blood vessels in the germinal matrix, is a prevalent driver of preterm brain injuries and death. Our group recently developed a model simulating GMH using intrastriatal injections of collagenase in 5-day-old rats, which corresponds to the brain development of human preterm infants. This study aimed to define changes to the blood-brain barrier (BBB) and to evaluate BBB proteins as biomarkers in this GMH model. Regional BBB functions were investigated using blood to brain

Indexed as

AnimalsAnimals, NewbornBiological TransportBiomarkersBlood-Brain BarrierCerebral HemorrhageClaudin-5CollagenasesCorpus StriatumDisease Models, AnimalGene ExpressionHematomaHumansInfant, NewbornInfant, PrematureInjections, IntraventricularBiomarkersClaudin-5Cldn5 protein, ratCollagenasesOccludinOcln protein, ratSucroseblood-brain barriergerminal matrix haemorrhageneonatal brainpretermtight-junctions

Identifiers

PMID34359845
PMCPMC8303246
OpenAlexW3177342634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.