ArticleCancers2021
Rapid Spectroscopic Liquid Biopsy for the Universal Detection of Brain Tumours.
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Is There a Role for Machine Learning in Liquid Biopsy for Brain Tumors? A Systematic Review.International journal of molecular sciences · 2023Pooled it
- A multi-centre performance evaluation of a commercially developed liquid biopsy for the earlier detection of brain tumours.ESMO open · 2026Observational
- Review
- Evaluation of an Image-based Classification Model to Identify Glioma Subtypes Using Arterial Spin Labeling Perfusion MRI On the Publicly Available UCSF Glioma Dataset.Clinical neuroradiology · 2025Article
- Comment on "Early cancer detection by serum biomolecular fingerprinting spectroscopy with machine learning".Light, science & applications · 2025Article
- Distinguishing IDH mutation status in gliomas using FTIR-ATR spectra of peripheral blood plasma indicating clear traces of protein amyloid aggregation.BMC cancer · 2024Article
- A spectroscopic liquid biopsy for the earlier detection of multiple cancer types.British journal of cancer · 2023Article
- Liquid biopsies: the future of cancer early detection.Journal of translational medicine · 2023Review
- Discovering Glioma Tissue through Its Biomarkers' Detection in Blood by Raman Spectroscopy and Machine Learning.Pharmaceutics · 2023Article
- Investigating centrifugal filtration of serum-based FTIR spectroscopy for the stratification of brain tumours.PloS one · 2023Article
- Rapid Detection of Recurrent Non-Muscle Invasive Bladder Cancer in Urine Using ATR-FTIR Technology.Molecules (Basel, Switzerland) · 2022Article
- Strategies, considerations, and recent advancements in the development of liquid biopsy for glioblastoma: a step towards individualized medicine in glioblastoma.Neurosurgical focus · 2022Review
- Unmet need for liquid biomarkers and the Brain-Liquid Biopsy Consortium.Neuro-oncology advances · 2022Article
- The future of brain tumor liquid biopsies in the clinic.Neuro-oncology advances · 2022Article
- Article
- Clinical validation of a spectroscopic liquid biopsy for earlier detection of brain cancer.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTo support the early detection and diagnosis of brain tumours we have developed a rapid, cost-effective and easy to use spectroscopic liquid biopsy based on the absorbance of infrared radiation. We have previously reported highly sensitive results of our approach which can discriminate patients with a recent brain tumour diagnosis and asymptomatic controls. Other liquid biopsy approaches (e.g., based on tumour genetic material) report a lower classification accuracy for early-stage tumours. In this manuscript we present an investigation into the link between brain tumour volume and liquid biopsy test performance.
methodsIn a cohort of 177 patients (90 patients with high-grade glioma (glioblastoma (GBM) or anaplastic astrocytoma), or low-grade glioma (astrocytoma, oligoastrocytoma and oligodendroglioma)) tumour volumes were calculated from magnetic resonance imaging (MRI) investigations and patients were split into two groups depending on MRI parameters (T1 with contrast enhancement or T2/FLAIR (fluid-attenuated inversion recovery)). Using attenuated total reflection (ATR)-Fourier transform infrared (FTIR) spectroscopy coupled with supervised learning methods and machine learning algorithms, 90 tumour patients were stratified against 87 control patients who displayed no symptomatic indications of cancer, and were classified as either glioma or non-glioma.
resultsSensitivities, specificities and balanced accuracies were all greater than 88%, the area under the curve (AUC) was 0.98, and cancer patients with tumour volumes as small as 0.2 cm
conclusionsOur spectroscopic liquid biopsy approach can identify gliomas that are both small and low-grade showing great promise for deployment of this technique for early detection and diagnosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.