ArticleCancers2021
Clinical Characteristics and Outcomes of Colorectal Cancer in the ColoCare Study: Differences by Age of Onset.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Early-onset colorectal cancer is associated with metabolic disorders: a systematic review and meta-analysis.European journal of epidemiology · 2026Pooled it
- Neoadjuvant chemotherapy is noninferior to chemoradiotherapy for early-onset locally advanced rectal cancer in the FOWARC trial.British journal of cancer · 2024Trial
- Emerging Roles for Metabolism in Myocardial Inflammation During Heart Failure.Immunological reviews · 2026Review
- Features of the Intestinal and Respiratory Microbiome in Colorectal Cancer Patients in Western Siberia.Microorganisms · 2026Article
- Article
- Risk Factors in Sporadic Early-Onset Colorectal Cancer, Current Evidence and Emerging Insights: A Systematic Review.Cancers · 2026Review
- Scorpio fuscus venom as a promising anticancer agent against colorectal cancer.Investigational new drugs · 2026Article
- H&E-based MSI/MMR testing with AI in colorectal cancer: a multi-centred blinded evaluation.NPJ digital medicine · 2025Article
- Genetic predisposition to persistent fatigue after a diagnosis of colorectal cancer.Journal of the National Cancer Institute · 2025Article
- Short-term surgical outcomes in patients with early- versus average-onset colon adenocarcinoma in the Military Health System.JNCI cancer spectrum · 2025Article
- Early- vs. late-onset colon cancer: clinicopathological insights and survival outcomes in an East Asian cohort.International journal of colorectal disease · 2025Observational
- Obesity as a risk factor for early-onset colorectal cancer: Evidence from a nationally representative database.World journal of clinical oncology · 2025Article
- A predictive nomogram for predicting liver metastasis in early-onset colon cancer: a population-based study.Translational cancer research · 2025Article
- Racial comparisons in treatment of rectal adenocarcinoma and survival in the military health system.JNCI cancer spectrum · 2024Article
- Short- and long-term outcome differences between patients undergoing left and right colon cancer surgery: cohort study.International journal of colorectal disease · 2024Article
- Functional quality of life among newly diagnosed young adult colorectal cancer survivors compared to older adults: results from the ColoCare Study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Observational
- Birth Cohort Colorectal Cancer (CRC): Implications for Research and Practice.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Review
- A competing risk nomogram to predict cancer-specific mortality of patients with late-onset colorectal cancer.Journal of cancer research and clinical oncology · 2023Article
- The analysis between clinicopathological aspect of early-onset vs. late-onset colorectal cancer and mortality rate: a cross-sectional study.Annals of medicine and surgery (2012) · 2023Article
- Associations of combined physical activity and body mass index groups with colorectal cancer survival outcomes.BMC cancer · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
58 authors at 10 institutions in 2 countries.
Caroline HimbertHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.ORCID 0000-0003-4084-8340
Jane C FigueiredoCedars-Sinai Center, Los Angeles, CA 90048, USA.
David ShibataDepartment of Surgery, University of Tennessee Health Science Center, Memphis, TN 37996, USA.
Jennifer OseHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.ORCID 0000-0002-2030-9676
Tengda LinHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Lyen C HuangHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.ORCID 0000-0002-8605-2631
Anita R PeoplesHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.ORCID 0000-0003-3645-3960
Courtney L ScaifeHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Bartley PickronHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Laura LambertHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Jessica N CohanHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.ORCID 0000-0002-5461-4716
Mary BronnerHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Seth FelderH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Julian SanchezH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Sophie DessureaultH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Domenico CoppolaH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
David M HoffmanCedars-Sinai Center, Los Angeles, CA 90048, USA.
Yosef F NasseriCedars-Sinai Center, Los Angeles, CA 90048, USA.
Robert W DeckerCedars-Sinai Center, Los Angeles, CA 90048, USA.
Karen ZaghiyanCedars-Sinai Center, Los Angeles, CA 90048, USA.
Zuri A MurrellCedars-Sinai Center, Los Angeles, CA 90048, USA.
Andrew HendifarCedars-Sinai Center, Los Angeles, CA 90048, USA.
Jun GongCedars-Sinai Center, Los Angeles, CA 90048, USA.
Eiman FiroozmandCedars-Sinai Center, Los Angeles, CA 90048, USA.
Alexandra GangiCedars-Sinai Center, Los Angeles, CA 90048, USA.
Beth A MooreCedars-Sinai Center, Los Angeles, CA 90048, USA.
Kyle G CologneCedars-Sinai Center, Los Angeles, CA 90048, USA.
Maryliza S El-MasryCedars-Sinai Center, Los Angeles, CA 90048, USA.
Nathan HinkleDepartment of Surgery, University of Tennessee Health Science Center, Memphis, TN 37996, USA.
Justin MonroeDepartment of Surgery, University of Tennessee Health Science Center, Memphis, TN 37996, USA.
Matthew MutchDepartment of Surgery, Washington University St. Louis, St. Louis, MO 63130, USA.
Cory BernadtDepartment of Surgery, Washington University St. Louis, St. Louis, MO 63130, USA.
Deyali ChatterjeeDepartment of Surgery, Washington University St. Louis, St. Louis, MO 63130, USA.
Mika SinananFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Stacey A CohenFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Ulrike WallinFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
William M GradyFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Paul D LampeFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.ORCID 0000-0002-1399-2761
Deepti ReddiFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Mukta KraneFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Alessandro FicheraBaylor Scott & White Health, Dallas, TX 76712, USA.ORCID 0000-0003-4205-4413
Ravi MoonkaFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Esther HerpelPathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Peter SchirmacherPathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Matthias KloorPathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Magnus von Knebel-DoeberitzPathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Johanna NattenmuellerPathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Hans-Ulrich KauczorPathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Eric SwansonHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Jolanta JedrzkiewiczHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Stephanie L SchmitH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Biljana GigicPathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-8085-2072
Alexis B UlrichPathologisches Institut, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-1469-2186
Adetunji T ToriolaDepartment of Surgery, Washington University St. Louis, St. Louis, MO 63130, USA.
Erin M SiegelH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.ORCID 0000-0003-1779-2510
Christopher I LiFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Cornelia M UlrichHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.ORCID 0000-0001-7641-059X
Sheetal HardikarHuntsman Cancer Institute, Salt Lake City, UT 84112, USA.ORCID 0000-0003-0292-6168
Cedars-Sinai Medical Center · USHeidelberg University · DEUniversity of Utah · USHuntsman Cancer Institute · USMoffitt Cancer Center · USFred Hutch Cancer Center · USUniversity of Washington · USWashington University in St. Louis · USUniversity of Tennessee Health Science Center · USBaylor Scott & White Health · US
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MWashington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5MUTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6MTransdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare StudyU01CA206110 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jane C. Figueiredo, Christopher I Li · 2016 to 2026
$18.6MIdentify and validate novel epigenetic molecular markers for colorectal neoplasmU01CA152756 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GRADY, WILLIAM MALLORY, GUDA, KISHORE · 2010 to 2021
$6.7MDiscovery and verification of novel biomarkers of colorectal cancer recurrenceR01CA189184 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LI, CHRISTOPHER I, ULRICH, CORNELIA M · 2015 to 2020
$5.6MVascular Health and Risk Factors in Children with Down SyndromeKL2TR002539 · NCATS · UNIVERSITY OF UTAH · PI MURTAUGH, MAUREEN A, NYGAARD, INGRID E · 2018 to 2022
$4.3MMetabolomic Strategies for Discovery and Validation of Biomarkers of Colorectal Cancer RecurrenceR01CA207371 · NCI · UNIVERSITY OF UTAH · PI LI, CHRISTOPHER I, ULRICH, CORNELIA M · 2017 to 2022
$3.9M(PQ6) Radiogenomics of colorectal polyps to assess benign proliferative vs. premalignant states.R01CA220004 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GRADY, WILLIAM MALLORY, HALBERG, RICHARD BROTT · 2017 to 2021
$3.2MPrecision-exercise-prescription for Lung Cancer Patients Undergoing Surgery: The PEP StudyR01CA211705 · NCI · UNIVERSITY OF UTAH · PI LASTAYO, PAUL C, ULRICH, CORNELIA M · 2017 to 2021
$2.2M(PQC1) Accelerated biological aging and colon polyp to cancer progressionR01CA194663 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GRADY, WILLIAM MALLORY · 2015 to 2018
$1.6MERA-NET Translational Cancer Research Program 01KT1503Florida Department of Health Bankhead Coley New Investigator AwardMatthias Lackas-Stiftung NANCATS NIH HHS KL2 TR002539NCI NIH HHS K07 222060NCI NIH HHS P30CA01570NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA042014NCI NIH HHS P30 CA076292NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA189184NCI NIH HHS R01CA194663NCI NIH HHS R01 CA207371NCI NIH HHS R01 CA211705NCI NIH HHS R01CA220004NCI NIH HHS U01206110NCI NIH HHS U01 CA152756NCI NIH HHS U01CA152756NCI NIH HHS U01 CA206110Seattle Translational Tumor Research Program NAStiftung LebensBlicke NA
Abstract
Early-onset colorectal cancer has been on the rise in Western populations. Here, we compare patient characteristics between those with early- (<50 years) vs. late-onset (≥50 years) disease in a large multinational cohort of colorectal cancer patients (
Indexed as
cohortcolorectal cancerearly onsetepidemiology
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What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT02328677ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.