Evidence map›Paper›PMID 34359584›Full record

ArticleCancers2021

Spyros Tastsoglou, Marios Miliotis, Ioannis Kavakiotis, Athanasios Alexiou, Eleni C Gkotsi, Anastasia Lambropoulou, Vasileios Lygnos, Vasiliki Kotsira, Vasileios Maroulis, Dimitrios Zisis and 2 more

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Role of miRNA in Cardiovascular Diseases in Children-Systematic Review.International journal of molecular sciences · 2024
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Hepatitis B Virus and microRNAs: A Bioinformatics Approach.International journal of molecular sciences · 2023
    Review
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Spyros TastsoglouHellenic Pasteur Institute, 11521 Athens, Greece.ORCID 0000-0002-0316-6239
Marios MiliotisHellenic Pasteur Institute, 11521 Athens, Greece.ORCID 0000-0003-4924-050X
Ioannis KavakiotisDIANA-Lab, Department of Computer Science and Biomedical Informatics, University of Thessaly, 35131 Lamia, Greece.
Athanasios AlexiouHellenic Pasteur Institute, 11521 Athens, Greece.
Eleni C GkotsiDepartment of Informatics and Telecommunications, Postgraduate Program: 'Information Technologies in Medicine and Biology', University of Athens, 15784 Athens, Greece.ORCID 0000-0002-9096-2064
Anastasia LambropoulouHellenic Pasteur Institute, 11521 Athens, Greece.
Vasileios LygnosHellenic Pasteur Institute, 11521 Athens, Greece.
Vasiliki KotsiraDIANA-Lab, Department of Computer Science and Biomedical Informatics, University of Thessaly, 35131 Lamia, Greece.
Vasileios MaroulisDepartment of Informatics and Telecommunications, Postgraduate Program: 'Information Technologies in Medicine and Biology', University of Athens, 15784 Athens, Greece.
Dimitrios ZisisHellenic Pasteur Institute, 11521 Athens, Greece.
Giorgos SkoufosHellenic Pasteur Institute, 11521 Athens, Greece.ORCID 0000-0001-9022-6334
Artemis G HatzigeorgiouHellenic Pasteur Institute, 11521 Athens, Greece.ORCID 0000-0003-1414-5668

Funding

Project "ELIXIR-GR: The Greek Research Infrastructure for Data Management and Analysis in Life Sciences" MIS-5002780
6 · The paper itself

Abstract

Only recently, microRNAs (miRNAs) were found to exist in traceable and distinctive amounts in the human circulatory system, bringing forth the intriguing possibility of using them as minimally invasive biomarkers. miRNAs are short non-coding RNAs that act as potent post-transcriptional regulators of gene expression. Extensive studies in cancer and other disease landscapes investigate the protective/pathogenic functions of dysregulated miRNAs, as well as their biomarker potential. A specialized resource amassing experimentally verified, circulating miRNA biomarkers does not exist. We queried the existing literature to identify articles assessing diagnostic/prognostic roles of miRNAs in blood, serum, or plasma samples. Articles were scrutinized in order to exclude instances lacking sufficient experimental documentation or employing no biomarker assessment methods. We incorporated information from more than 200 biomedical articles, annotating crucial meta-information including cohort sizes, inclusion-exclusion criteria, disease/healthy confirmation methods and quantification details. miRNAs and diseases were systematically characterized using reference resources. Our circulating miRNA biomarker collection is provided as an online database,

Indexed as

circulating biomarker collectioncirculating biomarker miRNA databasecirculating miRNAsdiagnostic miRNAsdisease biomarker assessmentprognostic miRNAs

Identifiers

PMID34359584
PMCPMC8345031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.