ReviewCancers2021
Fracture Risk of Long Bone Metastases: A Review of Current and New Decision-Making Tools for Prophylactic Surgery.
Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Diagnostic accuracy of the Mirels score at the humerus in metastatic bone disease: a narrative review.International orthopaedics · 2026Review
- Clinical, functional, and quality-of-life outcomes after arthroplasty versus osteosynthesis for metastatic lesions of the proximal femur: a 12-month observational cohort study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Observational
- Artificial Intelligence and Machine Learning in Bone Metastasis Management: A Narrative Review.Current oncology (Toronto, Ont.) · 2026Review
- OPTIModel scoring for metastatic bone tumors: A data-driven tool for surgical planning and prognosis.Joint diseases and related surgery · 2026Article
- Discrepancy between X-ray and CT assessment in the Mirels score for long bone metastasis.BMC musculoskeletal disorders · 2025Article
- The risk of pathological fractures after intralesional curettage in Atypical Cartilaginous Tumours: A retrospective cohort study.Journal of bone oncology · 2025Article
- Review
- Prognostic assessment of osteolytic lesions and mechanical properties of bones bearing breast cancer using neural network and finite element analysisMechanobiology in medicine · 2025Article
- Predictive Factors for Failed Nonsurgical Management of Long Bone Metastasis and Myeloma.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- Radiomics of baseline epicardial adipose tissue predicts left ventricular mass regression after transcatheter aortic valve replacement.Journal of geriatric cardiology : JGC · 2024Article
- Risk Factors and Impact on Survival of Pathological Fractures in Patients With Humeral Metastasis.Cureus · 2024Article
- Physical therapist management and coordination of care to prevent pathological hip fracture from metastatic disease: a case report.Frontiers in rehabilitation sciences · 2024Article
- Risk Factors for Early Postoperative Morbidity and Mortality following Extremity Metastatic Pathologic or Impending Fracture Fixation.International journal of surgical oncology · 2024Article
- The low and disproportionate utilization of antiresorptive therapy in patients with osseous metastasis.Journal of bone oncology · 2023Article
- Article
- A Multiparametric MRI-Based Radiomics Nomogram for Preoperative Prediction of Survival Stratification in Glioblastoma Patients With Standard Treatment.Frontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long bone pathological fractures very much reflect bone metastases morbidity in many types of cancer. Bearing in mind that they not only compromise patient function but also survival, identifying impending fractures before the actual event is one of the main concerns for tumor boards. Indeed, timely prophylactic surgery has been demonstrated to increase patient quality of life as well as survival. However, early surgery for long bone metastases remains controversial as the current fracture risk assessment tools lack accuracy. This review first focuses on the gold standard Mirels rating system. It then explores other unique imaging thresholds such as axial or circumferential cortical involvement and the merits of nuclear imaging tools. To overcome the lack of specificity, other fracture prediction strategies have focused on biomechanical models based on quantitative computed tomography (CT): computed tomography rigidity analysis (CT-RA) and finite element analysis (CT-FEA). Despite their higher specificities in impending fracture assessment, their limited availability, along with a need for standardization, have limited their use in everyday practice. Currently, the prediction of long bone pathologic fractures is a multifactorial process. In this regard, machine learning could potentially be of value by taking into account clinical survival prediction as well as clinical and improved CT-RA/FEA data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.