ArticleCancers2021
Natural History of Untreated Retinoblastoma.
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Environmental and Occupational Risk Factors for Retinoblastoma.AJPM focus · 2026Review
- Factors influencing delayed medical treatment in children with retinoblastoma: a qualitative study.BMC cancer · 2025Article
- High-risk features in retinoblastoma: the association between histopathology and MRI.BMJ open ophthalmology · 2025Article
- Update on Retinoblastoma Therapies.Medicina (Kaunas, Lithuania) · 2025Review
- Challenges and Outcomes of Retinoblastoma Treatment in Ethiopia A Case of Jimma University Medical Center, Southwest Ethiopia.Ethiopian journal of health sciences · 2025Article
- Retinoblastoma in a Young Nigerian Girl: A Case Report From ECWA Eye Hospital, Kano.Case reports in ophthalmological medicine · 2025Article
- Mimicking Retinoblastoma Treatment With Repeated Topotecan or Melphalan Develops Cross-Resistance to Classic Agents But Not to Repurposed Drugs.Investigative ophthalmology & visual science · 2024Article
- Intraocular Surgery for Retinoblastoma: An Evaluation of Current Evidence.Ocular oncology and pathology · 2024Review
- A prospective registry study of the epidemiology and management of childhood cancer in the Gambia-The first year experience.Health science reports · 2024Article
- Philippine retinoblastoma initiative multi-eye center study 2010-2020.International journal of ophthalmology · 2024Article
- Presentation pattern and survival rate of retinoblastoma following chemotherapy: a prospective study.BMC pediatrics · 2023Article
- The clinical diagnostic value of plasma miR-592 and miR-217-3p levels in retinoblastoma.Journal of medical biochemistry · 2022Article
- The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries.The Lancet. Global health · 2022Article
- Anemia and Bone Marrow Suppression After Intra-Arterial Chemotherapy in Children With Retinoblastoma: A Retrospective Analysis.Frontiers in oncology · 2022Article
- Article
- Tylectomy Safety in Salvage of Eyes with Retinoblastoma.Cancers · 2021Article
- Deep learning volumetrics reveal distinct clinical trajectories for pediatric low-grade gliomas under surveillance: A multicenter study.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment abandonment is a leading cause of death in children with retinoblastoma worldwide. We studied children who abandoned treatment upfront at diagnosis to delineate the natural history of untreated retinoblastoma. Studied were children who received no treatment, diagnosed between 2007 and 2017 at 29 Chinese centers. Data were retrospectively collected from medical chart reviews and interviews with each patient's family. During the study period, 44 children received no treatment after diagnosis of retinoblastoma. Clinical or radiologic evidence of orbital extension was available for 25 children, and radiologic evidence of systemic metastasis was available for 12 children. Median times from diagnosis of intraocular tumor to orbital disease was 13.7 months, orbital disease to metastasis was 2.6 months, and metastasis to death was 2.0 months. Children with brain metastasis had shorter survival than those with metastasis to other sites (median 1.0 vs. 3.1 months;
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.