Evidence map›Paper›PMID 34359543›Full record

ReviewFoods (Basel, Switzerland)2021

Probiotics for Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Guangsu Zhu, Jianxin Zhao, Hao Zhang, Wei Chen, Gang Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Trial
  7. Effects ofNutrients · 2022
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  15. Effect of intervention withJournal of clinical biochemistry and nutrition · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guangsu ZhuState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0002-9501-7379
Jianxin ZhaoState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Hao ZhangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Wei ChenState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Gang WangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0003-2007-2143

Funding

Fundamental Research Funds for the Central Universities JUSRP22006Fundamental Research Funds for the Central Universities JUSRP51501National First-class Discipline Program of Food Science and Technology JUFSTR20180102National Natural Science Foundation of China 31820103010National Natural Science Foundation of China 31972052National Natural Science Foundation of China 32021005
6 · The paper itself

Abstract

Accumulating evidence from animal studies supports the potential role of probiotics and prebiotics in alleviating neurodegenerative diseases. However, whether dietary supplementation with probiotics improves cognitive function in patients with Alzheimer's disease (AD) or mild cognitive impairment (MCI) is unclear. We searched literature databases for relevant randomized control trials and compared the outcomes between control/placebo and intervention groups. The results of the included studies were meta-analyzed using a random-effects model, with standardized mean differences (SMDs) and 95% confidence intervals (CIs) calculated as summary statistics. We also performed a risk-of-bias assessment, sensitivity analysis and subgroup analysis. Among the 294 articles identified, eight articles involving 174 patients with AD and 446 with MCI were included in the qualitative synthesis and seven studies were meta-analyzed. Our analysis detected high between-group heterogeneity (SMD = 0.43, 95% CI -0.02-0.88,

Indexed as

Alzheimer’s diseasecognitionmeta-analysismild cognitive impairmentprobiotics

Identifiers

PMID34359543
PMCPMC8303183

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.