ReviewFoods (Basel, Switzerland)2021
Bioaccessibility and Bioactivity of Cereal Polyphenols: A Review.
Review in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- The impact of single nucleotide polymorphisms on the absorption, distribution, metabolism, and excretion of dietary (poly)phenols: a critical systematic review.Food & function · 2025Pooled it
- Unlocking Antioxidant Potential in Wheat By-Products Through Microbial Bioprocessing: An Integrated Extraction-QUENCHER Assessment.Molecules (Basel, Switzerland) · 2026Article
- Influence of Simulated Gastrointestinal Digestion on Phenolic Composition, Bioaccessibility, and Antioxidant Properties of Commercial Wild Rice.Molecules (Basel, Switzerland) · 2026Article
- Prebiotic Potential of Brewer's Spent Grain Residual Solid After Enzymatic Hydrolysis: Evidence from a Colonic Fermentation Study.Foods (Basel, Switzerland) · 2026Article
- Lysozyme-induced 3D assembly of quercetin-zinc rod-like nanocolloids and its functional impact on antioxidant, gut microbiota, and lipid metabolism.Food chemistry: X · 2026Article
- Preventive Effect ofNutrients · 2026Article
- The Germination Paradox in Sorghum: A Review.Foods (Basel, Switzerland) · 2026Review
- Spatial metabolomics reveals seed coat-specific accumulation of bioactive polyphenols inFood chemistry: X · 2025Article
- Gastrointestinal Digestion Impact on Phenolics and Bioactivity of Tannat Grape Pomace Biscuits.Molecules (Basel, Switzerland) · 2025Article
- Review
- SIRT1-Mediated Epigenetic Protective Mechanisms of Phytosome-EncapsulatedInternational journal of molecular sciences · 2025Article
- Evaluation of the Bioaccessibility of Essential and Toxic Trace Elements in Basil, Peppermint, and Rosemary Using an In Vitro Gastrointestinal Digestion Model.Journal of agricultural and food chemistry · 2025Article
- The Bioaccessibility of Grape-Derived Phenolic Compounds: An Overview.Foods (Basel, Switzerland) · 2025Review
- The Release of Bound Phenolics to Enhance the Antioxidant Activity of Cornmeal by Liquid Fermentation withFoods (Basel, Switzerland) · 2025Article
- A Comprehensive Review on Polyphenols based Nanovesicular System for Topical Delivery.Current drug delivery · 2025Review
- Overview of the Metabolite Composition and Antioxidant Capacity of Seven Major and Minor Cereal Crops and Their Milling Fractions.Journal of agricultural and food chemistry · 2024Article
- Effect of gastrointestinal digestion on the stability, antioxidant activity, and Caco-2 cellular transport of pigmented grain polyphenols.Journal of food science · 2024Article
- Article
- Metabolomics Characterization of Phenolic Compounds in Colored Quinoa and Their Relationship with In Vitro Antioxidant and Hypoglycemic Activities.Molecules (Basel, Switzerland) · 2024Article
- UV-induced reactive oxygen species and transcriptional control of 3-deoxyanthocyanidin biosynthesis in black sorghum pericarp.Frontiers in plant science · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cereal bioactive compounds, especially polyphenols, are known to possess a wide range of disease preventive properties that are attributed to their antioxidant and anti-inflammatory activity. However, due to their low plasma concentrations after oral intake, there is controversy regarding their therapeutic benefits in vivo. Within the gastrointestinal tract, some cereal polyphenols are absorbed in the small intestine, with the majority accumulating and metabolised by the colonic microbiota. Chemical and enzymatic processes occurring during gastrointestinal digestion modulate the bioactivity and bioaccessibility of phenolic compounds. The interactions between the cereal polyphenols and the intestinal epithelium allow the modulation of intestinal barrier function through antioxidant, anti-inflammatory activity and mucin production thereby improving intestinal health. The intestinal microbiota is believed to have a reciprocal interaction with polyphenols, wherein the microbiome produces bioactive and bioaccessible phenolic metabolites and the phenolic compound, in turn, modifies the microbiome composition favourably. Thus, the microbiome presents a key link between polyphenol consumption and the health benefits observed in metabolic conditions in numerous studies. This review will explore the therapeutic value of cereal polyphenols in conjunction with their bioaccessibility, impact on intestinal barrier function and interaction with the microbiome coupled with plasma anti-inflammatory effects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.