Evidence map›Paper›PMID 34359382›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Statistical Methods to Support Difficult Diagnoses.

Guenter F Pilz, Frank Weber, Werner G Mueller, Juergen R Schaefer

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guenter F PilzInstitute of Algebra, Johannes Kepler University, 4040 Linz, Austria.ORCID 0000-0001-7099-2963
Frank WeberGerman Air Force Center of Aerospace Medicine, 82256 Fuerstenfeldbruck, Germany.ORCID 0000-0001-8285-5544
Werner G MuellerInstitute for Applied Statistics, Johannes Kepler University, 4040 Linz, Austria.ORCID 0000-0002-3564-766X
Juergen R SchaeferCenter for Undiagnosed and Rare Diseases (ZusE), Philipps University, 35043 Marburg, Germany.ORCID 0000-0001-8320-3206

Funding

Austrian Science Fund FWF I 3903
6 · The paper itself

Abstract

Far too often, one meets patients who went for years or even decades from doctor to doctor without obtaining a valid diagnosis. This brings pain to millions of patients and their families, not to speak of the enormous costs. Often patients cannot tell precisely enough which factors (or combinations thereof) trigger their problems. If conventional methods fail, we propose the use of statistics and algebra to provide doctors much more useful inputs from patients. We use statistical regression for triggering factors of medical problems, and in particular, "balanced incomplete block designs" for factors detection. These methods can supply doctors with much more valuable inputs and can also find combinations of multiple factors through very few tests. In order to show that these methods do work, we briefly describe a case in which these methods helped to solve a 60-year-old problem in a patient and provide some more examples where these methods might be particularly useful. As a conclusion, while regression is used in clinical medicine, it seems to be widely unknown in diagnosing. Statistics and algebra can save the health systems much money, as well as the patients a lot of pain.

Indexed as

block designsdiagnosing designsrare diseasesregressionstatistics

Identifiers

PMID34359382
PMCPMC8305132

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.