Evidence map›Paper›PMID 34359373›Full record

ArticleDiagnostics (Basel, Switzerland)2021

HLA-A29 Birdshot Retinochoroiditis in Its 5th Decade: Selected Glimpses into the Intellectual Meanderings and Progresses in the Knowledge of a Long-Time Misunderstood Disease.

Marina Papadia, Carlos Pavésio, Christine Fardeau, Piergiorgio Neri, Philippe G Kestelyn, Ioannis Papasavvas, Carl P Herbort

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Some practical issues about HLA-A29 in birdshot retinochoroiditis.Journal of ophthalmic inflammation and infection · 2023
    Article
  6. Article
  7. Article
  8. Birdshot Chorioretinopathy: A Review.Journal of clinical medicine · 2022
    Review
  9. Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 5 countries.

Marina PapadiaIstituto Auxologico Italiano IRCCS, 20095 Milano, Italy.
Carlos PavésioMoorfields Eye Hospital and Biomedical Research Centre, UCL, London EC1V 2PD, UK.
Christine FardeauReference Center for Rare Diseases, Department of Ophthalmology, La Pitié-Salpêtrière Hospital, Paris-Sorbonne University, 75013 Paris, France.ORCID 0000-0003-1935-2711
Piergiorgio NeriUveitis Service, Cleveland Clinic Abu Dhabi, Abu Dhabi Island-59, United Arab Emirates.ORCID 0000-0002-7673-4276
Philippe G KestelynGhent University, 9000 Ghent, Belgium.
Ioannis PapasavvasRetinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialised Care (COS), Montchoisi Teaching Centre, Rue Charles-Monnard 6, 1003 Lausanne, Switzerland.ORCID 0000-0002-8930-5112
Carl P HerbortRetinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialised Care (COS), Montchoisi Teaching Centre, Rue Charles-Monnard 6, 1003 Lausanne, Switzerland.
Cleveland Clinic Lerner College of Medicine · USGhent University Hospital · BEIRCCS Istituto Auxologico Italiano · ITMoorfields Eye Hospital · GBSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The appraisal of HLA-A29 birdshot retinochoroiditis (BRC) was fraught with pitfalls and misunderstandings. Progress in investigational methods has led to better knowledge and management of the disease. Our aim was to assess some of the steps that have led to better characterisation of the clinical entity of BRC. We performed a literature search analysing the relevant progress in disease origin, investigational and imaging methods, clinicopathology and classification, diagnostic criteria and management. Following developments were judged essential in the better appraisal and understanding of the disease: (1) new immunopathological hypotheses regarding the role of endoplasmic reticulum peptidases, (2) the essential importance of HLA testing, (3) relevant imaging modalities among which indocyanine green angiography is crucial, (4) diagnostic criteria that allow early diagnosis and (5) need of an early prolonged, as well as aggressive treatment combining more than one immunosuppressive agent. Based on these findings it is now possible to better define BRC, an indolent however severe disease, unlike thought before, involving the choroidal stroma and the retina independently and concomitantly that can be diagnosed early thanks to indocyanine green angiography and should be treated early and relentlessly.

Indexed as

clinicopathologydiagnostic criteriafluorescein angiographyHLA-A29 birdshot retinochoroiditisimmunopathologyindocyanine green angiographyoptical coherence tomography

Identifiers

PMID34359373
PMCPMC8305470
OpenAlexW3185615541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.