ArticleDiagnostics (Basel, Switzerland)2021
Are Semi-Quantitative Clinical Cultures Inadequate? Comparison to Quantitative Analysis of 1053 Bacterial Isolates from 350 Wounds.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Clinical Utility of Autofluorescence Imaging for Bacterial Detection in Wounds: A Systematic Review.International wound journal · 2025Pooled it
- Reliance on Clinical Signs and Symptoms Assessment Leads to Misuse of Antimicrobials:Advances in wound care · 2022Trial
- Combined bacteriophage and antibiotic therapy for refractory peritoneal dialysis-related peritonitis caused by Klebsiella pneumoniae.Nature communications · 2026Article
- Old but gold: an historical perspective of wet mount microscopy and its current role for the diagnosis of vaginitis.Frontiers in reproductive health · 2026Review
- Use of saline-soaked bacterial culture swabs increases bacterial recovery in dogs with superficial bacterial folliculitis.Veterinary dermatology · 2025Article
- Current and Future Directions in Fluorescence Imaging-Guided Debridement.Advances in wound care · 2025Review
- Porcine model of a complicated skin and soft tissue infection caused byVeterinarni medicina · 2024Article
- Skin Pigmentation Impacts the Clinical Diagnosis of Wound Infection: Imaging of Bacterial Burden to Overcome Diagnostic Limitations.Journal of racial and ethnic health disparities · 2024Article
- Integrating Point-of-Care Bacterial Fluorescence Imaging-Guided Care with Continued Wound Measurement for Enhanced Wound Area Reduction Monitoring.Diagnostics (Basel, Switzerland) · 2023Article
- Point-of-care fluorescence imaging to optimise wound bed preparation prior to cellular and/or tissue-based product (CTP) application.International wound journal · 2023Article
- First-in-human application of double-stranded RNA bacteriophage in the treatment of pulmonary Pseudomonas aeruginosa infection.Microbial biotechnology · 2023Article
- Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review.Microorganisms · 2023Review
- Fluorescence - modern method of the diagnosis of chronic wounds on the example of venous leg ulcer.Postepy dermatologii i alergologii · 2023Article
- Point-of-care fluorescence imaging reveals extent of bacterial load in diabetic foot ulcers.International wound journal · 2023Article
- Development of an implantable three-dimensional model of a functional pathogenic multispecies biofilm to study infected wounds.Scientific reports · 2022Article
- Uncovering the high prevalence of bacterial burden in surgical site wounds with point-of-care fluorescence imaging.International wound journal · 2022Article
- Use of fluorescence imaging to optimize location of tissue sampling in hard-to-heal wounds.Frontiers in cellular and infection microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early awareness and management of bacterial burden and biofilm is essential to wound healing. Semi-quantitative analysis of swab or biopsy samples is a relatively simple method for measuring wound microbial load. The accuracy of semi-quantitative culture analysis was compared to 'gold standard' quantitative culture analysis using 428 tissue biopsies from 350 chronic wounds. Semi-quantitative results, obtained by serial dilution of biopsy homogenates streaked onto culture plates divided into 4 quadrants representing occasional, light, moderate, and heavy growth, were compared to total bacterial load quantified as colony-forming units per gram (CFU/g). Light growth, typically considered an insignificant finding, averaged a clinically significant 2.5 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.