Evidence map›Paper›PMID 34359231›Full record

ArticleAnimals : an open access journal from MDPI2021

An N-ethyl-N-Nitrosourea Mutagenesis Screen in Mice Reveals a Mutation in

Maria Alba Sorolla, Marta Marqués, Eva Parisi, Anabel Sorolla

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Professor Emma Whitelaw, a pioneer of epigenetic inheritance.Frontiers in epigenetics and epigenomics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Maria Alba SorollaResearch Group of Cancer Biomarkers, Lleida Institute for Biomedical Research Dr. Pifarré Foundation IRBLleida, 25198 Lleida, Spain.ORCID 0000-0002-2180-0408
Marta MarquésDepartment of Medicine, University of Lleida, 25198 Lleida, Spain.ORCID 0000-0003-4905-8345
Eva ParisiResearch Group of Cancer Biomarkers, Lleida Institute for Biomedical Research Dr. Pifarré Foundation IRBLleida, 25198 Lleida, Spain.
Anabel SorollaResearch Group of Cancer Biomarkers, Lleida Institute for Biomedical Research Dr. Pifarré Foundation IRBLleida, 25198 Lleida, Spain.ORCID 0000-0001-8238-8763
Instituto de Investigación Biomédica de Lleida · ESQIMR Berghofer Medical Research Institute · AUUniversitat de Lleida · ES

Funding

Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SRG1620H2020 Marie Skłodowska-Curie Actions 893384Instituto de Salud Carlos III CP20/00039Merck Salud 2018 Project awardNational Health and Medical Research Council APP0552445Raine Medical Research Foundation RPG-004-19
6 · The paper itself

Abstract

We have established a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen to identify novel genes playing a role in epigenetic regulation in mammals. We hypothesize that the ENU mutagenesis screen will lead to the discovery of unknown genes responsible of the maintenance of the epigenetic state as the genes found are modifiers of variegation of the transgene green fluorescent protein (GFP) expression in erythrocytes, which are named

Indexed as

DNA methylationembryonic developmentENU mutagenesisepigeneticsNrf1NRF1transcription factor

Identifiers

PMID34359231
PMCPMC8300126
OpenAlexW3180812107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.