Evidence map›Paper›PMID 34359176›Full record

ArticleAnimals : an open access journal from MDPI2021

Anti-Aging Effect of Urolithin A on Bovine Oocytes

Élisa Fonseca, Carla Cruz Marques, Jorge Pimenta, Joana Jorge, Maria Conceição Baptista, Ana Cristina Gonçalves, Rosa M L N Pereira

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Élisa FonsecaInstituto Nacional de Investigação Agrária e Veterinária, Quinta da Fonte Boa, 2005-048 Santarem, Portugal.ORCID 0000-0002-1654-143X
Carla Cruz MarquesInstituto Nacional de Investigação Agrária e Veterinária, Quinta da Fonte Boa, 2005-048 Santarem, Portugal.
Jorge PimentaInstituto Nacional de Investigação Agrária e Veterinária, Quinta da Fonte Boa, 2005-048 Santarem, Portugal.
Joana JorgeGroup of Environment, Genetics and Oncobiology, Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research, University Coimbra, 3000-548 Coimbra, Portugal.
Maria Conceição BaptistaInstituto Nacional de Investigação Agrária e Veterinária, Quinta da Fonte Boa, 2005-048 Santarem, Portugal.
Ana Cristina GonçalvesGroup of Environment, Genetics and Oncobiology, Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research, University Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0003-1470-4802
Rosa M L N PereiraInstituto Nacional de Investigação Agrária e Veterinária, Quinta da Fonte Boa, 2005-048 Santarem, Portugal.ORCID 0000-0002-7514-6130
Instituto Nacional de Investigação Agrária e Veterinária · PTUniversity of Coimbra · PTUniversity of Lisbon · PT

Funding

Fundação para a Ciencia e Tecnologia PTDC/CVT-REP/2863/2012Fundação para a Ciencia e Tecnologia SFRH/BD/145531/2019Fundação para a Ciencia e Tecnologia UIDB/00276/2020Fundação para a Ciencia e Tecnologia UIDB/04539/2020Rural Development Programme PDR2020-101-03112
6 · The paper itself

Abstract

Oxidative stress and mitochondrial dysfunction have been associated with the age-related decline of oocyte quality and strategies for their prevention are currently quested. Urolithin A (UA) is a natural metabolite with pro-apoptotic and antioxidant effects, capable of preventing the accumulation of dysfunctional mitochondria in different aged cells. UA has never been tested in bovine oocytes. Our aim was to study the effect of UA on the developmental potential of cumulus-oocyte-complexes (COCs) and granulosa cells' (GCs) expression of important genes related to reproductive competence. Nuclear maturation progression, mitochondrial membrane potential (MMP) and developmental competence of physiologically mature (22 h) and

Indexed as

agingassisted reproductive technologiesoocyteUrolithin A

Identifiers

PMID34359176
PMCPMC8300261
OpenAlexW3181913237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.