Evidence map›Paper›PMID 34358977›Full record

ArticlePsychiatry research. Neuroimaging2021

Aberrant activation of the mentalizing brain system during eye gaze discrimination in bipolar disorder.

Ivy F Tso, Cynthia Z Burton, Carly A Lasagna, Saige Rutherford, Beier Yao, Scott J Peltier, Timothy D Johnson, Melvin G McInnis, Stephan F Taylor

Abstract read
In one paragraph

Article in Psychiatry research. Neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ivy F TsoDepartment of Psychiatry, University of Michigan, Ann Arbor, United States. Electronic address: ivytso@umich.edu.
Cynthia Z BurtonDepartment of Psychiatry, University of Michigan, Ann Arbor, United States.
Carly A LasagnaDepartment of Psychiatry, University of Michigan, Ann Arbor, United States.
Saige RutherfordDepartment of Psychiatry, University of Michigan, Ann Arbor, United States; Radboud University Medical Centre, Nijmegen, the Netherlands.
Beier YaoDepartment of Psychology, Michigan State University, United States.
Scott J PeltierFunctional MRI Laboratory, University of Michigan, Ann Arbor, United States; Department of Biomedical Engineering, University of Michigan, Ann Arbor, United States.
Timothy D JohnsonDepartment of Biostatistics, University of Michigan, Ann Arbor, United States.
Melvin G McInnisDepartment of Psychiatry, University of Michigan, Ann Arbor, United States.
Stephan F TaylorDepartment of Psychiatry, University of Michigan, Ann Arbor, United States.

Funding

Multi-modal assessment of GABA function in psychosisR01MH118634 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TAYLOR, STEPHAN F · 2019 to 2023
$3.3M
Disrupted eye gaze perception as a biobehavioral marker of social dysfunction: An RDoC investigationR01MH122491 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TSO, IVY FEI · 2020 to 2024
$2.9M
Michigan Institute for Clinical and Health Research (MCHR)KL2TR000434 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$1.7M
Neural mechanisms of eye gaze perception in schizophreniaK23MH108823 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TSO, IVY FEI · 2016 to 2020
$894k
NCATS NIH HHS KL2 TR000434NIMH NIH HHS K23 MH108823NIMH NIH HHS R01 MH118634NIMH NIH HHS R01 MH122491
6 · The paper itself

Abstract

Bipolar disorder (BD) is associated with a range of social cognitive deficits. This study investigated the functioning of the mentalizing brain system in BD probed by an eye gaze perception task during fMRI. Compared with healthy controls (n = 21), BD participants (n = 14) showed reduced preferential activation for self-directed gaze discrimination in the medial prefrontal cortex (mPFC) and temporo-parietal junction (TPJ), which was associated with poorer cognition/social cognition. Aberrant functions of the mentalizing system should be further investigated as marker of social dysfunction and treatment targets.

Indexed as

Bipolar DisorderMentalizationBrainBrain MappingFixation, OcularHumansBipolar disorderfMRISocial cognition

Identifiers

PMID34358977
PMCPMC8387449

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.