ArticleBrain stimulation
Evoking highly focal percepts in the fingertips through targeted stimulation of sulcal regions of the brain for sensory restoration.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- A neuroprosthesis for restoring hand movement and sensation in a person with complete tetraplegia.Nature medicine · 2026Article
- Training-Free Regulation of Grasping by Intracortical Tactile Feedback Designed via S1-M1 Communication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Patterned electrical brain stimulation by a wireless network of implantable microdevices.Nature communications · 2024Article
- Clinical Applications and Future Translation of Somatosensory Neuroprostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- High-frequency amplitude-modulated sinusoidal stimulation induces desynchronized yet controllable neural firing.bioRxiv : the preprint server for biology · 2024Article
- Sensory Restoration for Improved Motor Control of Prostheses.Current opinion in biomedical engineering · 2023Article
- Neuropsychological outcomes after epilepsy surgery: A comparison of stereo electroencephalography and subdural electrodes.European journal of neurology · 2023Article
- Targeted transcutaneous spinal cord stimulation promotes persistent recovery of upper limb strength and tactile sensation in spinal cord injury: a pilot study.Frontiers in neuroscience · 2023Article
- Mechanical digit sensory stimulation: a randomized control trial on neurological and motor recovery in acute stroke.Frontiers in neuroscience · 2023Article
- Characterizing the short-latency evoked response to intracortical microstimulation across a multi-electrode array.Journal of neural engineering · 2022Article
- Beyond body maps: Information content of specific body parts is distributed across the somatosensory homunculus.Cell reports · 2022Article
- The Human Connectome Project: A retrospective.NeuroImage · 2021Review
- Recent developments in representations of the connectome.NeuroImage · 2021Review
- Historical perspectives, challenges, and future directions of implantable brain-computer interfaces for sensorimotor applications.Bioelectronic medicine · 2021Review
- Summary of over Fifty Years with Brain-Computer Interfaces-A Review.Brain sciences · 2021Review
- Case Study: Mapping Evoked Fields in Primary Motor and Sensory AreasFrontiers in neurology · 2021Article
- Decoding Neural Activity in Sulcal and White Matter Areas of the Brain to Accurately Predict Individual Finger Movement and Tactile Stimuli of the Human Hand.Frontiers in neuroscience · 2021Article
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Authors and funding
12 authors at 3 institutions in 1 country.
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Abstract
backgroundParalysis and neuropathy, affecting millions of people worldwide, can be accompanied by significant loss of somatosensation. With tactile sensation being central to achieving dexterous movement, brain-computer interface (BCI) researchers have used intracortical and cortical surface electrical stimulation to restore somatotopically-relevant sensation to the hand. However, these approaches are restricted to stimulating the gyral areas of the brain. Since representation of distal regions of the hand extends into the sulcal regions of human primary somatosensory cortex (S1), it has been challenging to evoke sensory percepts localized to the fingertips. OBJECTIVE/HYPOTHESIS: Targeted stimulation of sulcal regions of S1, using stereoelectroencephalography (SEEG) depth electrodes, can evoke focal sensory percepts in the fingertips.
methodsTwo participants with intractable epilepsy received cortical stimulation both at the gyri via high-density electrocorticography (HD-ECoG) grids and in the sulci via SEEG depth electrode leads. We characterized the evoked sensory percepts localized to the hand.
resultsWe show that highly focal percepts can be evoked in the fingertips of the hand through sulcal stimulation. fMRI, myelin content, and cortical thickness maps from the Human Connectome Project elucidated specific cortical areas and sub-regions within S1 that evoked these focal percepts. Within-participant comparisons showed that percepts evoked by sulcal stimulation via SEEG electrodes were significantly more focal (80% less area; p = 0.02) and localized to the fingertips more often, than by gyral stimulation via HD-ECoG electrodes. Finally, sulcal locations with consistent modulation of high-frequency neural activity during mechanical tactile stimulation of the fingertips showed the same somatotopic correspondence as cortical stimulation.
conclusionsOur findings indicate minimally invasive sulcal stimulation via SEEG electrodes could be a clinically viable approach to restoring sensation.
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