ArticleMolecular plant2021
A single-cell morpho-transcriptomic map of brassinosteroid action in the Arabidopsis root.
Article in Molecular plant, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 82 citations in OpenAlex.
- Cell-type specific early perception of nine phytohormones revealed by single-nucleus transcriptomics in Arabidopsis.Nature communications · 2026Article
- AGP and EXO-LIKE genes promote brassinosteroid-dependent anisotropic growth.The New phytologist · 2026Article
- Brassinosteroids control cell proliferation in the lateral root cap of the Arabidopsis root.EMBO reports · 2026Article
- Integrated single cell transcriptomics analysis for unraveling heterogeneity and plasticity of root cells for sustainable and regenerative agriculture.Frontiers in plant science · 2026Review
- Specificity of brassinosteroid perception and its integration at signaling crossroads in vascular development.The Plant journal : for cell and molecular biology · 2025Review
- An ABA-ROP toggle switch orchestrates xylem differentiation and cell wall patterning.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- BZR1 promotes pluripotency acquisition and callus development through direct regulation of ARF7 and ARF19.EMBO reports · 2025Article
- Root growth and branching are enabled by brassinosteroid-regulated growth anisotropy and carbon allocation.Nature communications · 2025Article
- Endophytic and Rhizospheric Microorganisms: An Alternative for Sustainable, Organic, and Regenerative Bioinput Formulations for Modern Agriculture.Microorganisms · 2025Review
- Modeling Arabidopsis root growth and development.Plant physiology · 2025Review
- Antagonistic CLE peptide pathways shape root meristem tissue patterning.Nature plants · 2024Article
- Topological analysis of 3D digital ovules identifies cellular patterns associated with ovule shape diversity.Development (Cambridge, England) · 2024Article
- The brassinosteroid receptor geneScience advances · 2024Article
- A deep learning-based toolkit for 3D nuclei segmentation and quantitative analysis in cellular and tissue context.Development (Cambridge, England) · 2024Article
- Nitrogen sensing and regulatory networks: it's about time and space.The Plant cell · 2024Review
- A century of studying plant secondary metabolism-From "what?" to "where, how, and why?"Plant physiology · 2024Review
- Best practices for the execution, analysis, and data storage of plant single-cell/nucleus transcriptomics.The Plant cell · 2024Article
- Quantitative analysis of lateral root development with time-lapse imaging and deep neural network.Quantitative plant biology · 2024Article
- The maize preligule band is subdivided into distinct domains with contrasting cellular properties prior to ligule outgrowth.Development (Cambridge, England) · 2023Article
- Transcriptional Landscape of Cotton Roots in Response to Salt Stress at Single-cell Resolution.Plant communications · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
The effects of brassinosteroid signaling on shoot and root development have been characterized in great detail but a simple consistent positive or negative impact on a basic cellular parameter was not identified. In this study, we combined digital 3D single-cell shape analysis and single-cell mRNA sequencing to characterize root meristems and mature root segments of brassinosteroid-blind mutants and wild type. The resultant datasets demonstrate that brassinosteroid signaling affects neither cell volume nor cell proliferation capacity. Instead, brassinosteroid signaling is essential for the precise orientation of cell division planes and the extent and timing of anisotropic cell expansion. Moreover, we found that the cell-aligning effects of brassinosteroid signaling can propagate to normalize the anatomy of both adjacent and distant brassinosteroid-blind cells through non-cell-autonomous functions, which are sufficient to restore growth vigor. Finally, single-cell transcriptome data discern directly brassinosteroid-responsive genes from genes that can react non-cell-autonomously and highlight arabinogalactans as sentinels of brassinosteroid-dependent anisotropic cell expansion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.