Evidence map›Paper›PMID 34358661›Full record

ArticleNeuroImage2021

FreeSurfer based cortical mapping and T1-relaxometry with MPnRAGE: Test-retest reliability with and without retrospective motion correction.

Steven Kecskemeti, Abigail Freeman, Brittany G Travers, Andrew L Alexander

Abstract read
In one paragraph

Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  6. Article
  7. Article
  8. Role of autonomic, nociceptive, and limbic brainstem nuclei in core autism features.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Steven KecskemetiWaisman Center, University of Wisconsin, Madison, United States; Radiology, University of Wisconsin, Madison, United States. Electronic address: kecskemeti@wisc.edu.
Abigail FreemanWaisman Center, University of Wisconsin, Madison, United States; Psychiatry, University of Wisconsin, Madison, United States.
Brittany G TraversKinesiology, University of Wisconsin, Madison, United States.
Andrew L AlexanderWaisman Center, University of Wisconsin, Madison, United States; Medical Physics, University of Wisconsin, Madison, United States; Psychiatry, University of Wisconsin, Madison, United States.

Funding

Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AMY J. KIND · 2019 to 2026
$34.5M
Summer Research ExperienceP50MH100031 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI KALIN, NED H · 2013 to 2017
$10.4M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI POLLAK, SETH D · 2016 to 2020
$6.0M
Alzheimer's Disease Connectome ProjectUF1AG051216 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI BENDLIN, BARBARA BRIGITTA, LI, SHI-JIANG · 2016 to 2019
$5.8M
White matter degeneration: biomarkers in preclinical Alzheimer's DiseaseR01AG037639 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA · 2012 to 2023
$5.3M
Brainstem Contributions to Sensorimotor and Core Symptoms in Children with Autism Spectrum DisorderR01HD094715 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Brittany Gail Travers · 2018 to 2026
$3.4M
Biological Determinants of Brain Variation in AutismR01MH097464 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI LAINHART, JANET ELIZABETH, LANGE, NICHOLAS T · 2013 to 2017
$2.9M
Validating RDoC for Children and Adolescents: A Twin Study with NeuroimagingR01MH101504 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDSMITH, HAROLD HILL · 2014 to 2017
$2.4M
3/3; Promoting resilience in children:Protocol Development for a Birth Cohort Study to Access Factors Impacting NeurodevelopmentR34DA050258 · NIDA · UNIVERSITY OF WISCONSIN-MADISON · PI ALEXANDER, ANDREW L · 2019 to 2019
$523k
NIA NIH HHS P30 AG062715NIA NIH HHS R01 AG037639NIA NIH HHS UF1 AG051216NICHD NIH HHS R01 HD094715NICHD NIH HHS U54 HD090256NIDA NIH HHS R34 DA050258NIMH NIH HHS P50 MH100031NIMH NIH HHS R01 MH097464NIMH NIH HHS R01 MH101504
6 · The paper itself

Abstract

A test-retest study of FreeSurfer derived cortical thickness, cortical surface area, and cortical volume, as well as quantitative R1 relaxometry assessed on the midpoint of the cortex, was performed on a cohort of pediatric subjects (6-12 years old) scanned without sedation using SNARE-MPnRAGE (self navigated retrospective motion corrected magnetization prepared with n rapid gradient echoes) imaging. Reliability was assessed with coefficients of variation (CoVs) and intraclass correlation coefficients (ICCs) and statistical tests were used to determine differences with and without SNARE motion correction. Comparison of the test-retest measures of SNARE-MPnRAGE with prospectively motion corrected PROMO MPRAGE were also performed. When SNARE motion correction was used all parameters had statistically significant improvements and demonstrated high reliability. Reliability varied depending on parameter, region, and measurement type (vertex or region of interest). For mean thickness/surface area/volume/mean R1 across the regions of FreeSurfer's DK Atlas, the mean CoVs (% x100) were (1.2/1.6/1.9/0.9) and the mean ICCs were (0.88/0.96/0.94/0.83). When assessed on a per-vertex basis, the CoVs and ICCs for thickness/R1 had mean values of (2.9/1.9) and (0.82/0.68) across the regions of the DK Atlas. Retrospectively motion corrected MPnRAGE had significantly lower CoVs and higher ICCs for the morphological measures than PROMO MPRAGE. Motion correction effectively removed motion related biases in nearly all regions for R1 and morphometric measures.

Indexed as

Brain Cortical ThicknessAdolescentCerebral CortexChildFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMotionReproducibility of ResultsCortexFreesurferMotionRelaxometryReliabilityRetest

Identifiers

PMID34358661
PMCPMC8525331

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.