Evidence map›Paper›PMID 34358645›Full record

ArticleThe Journal of nutritional biochemistry2021

Ceramide synthase 6 mediates sex-specific metabolic response to dietary folic acid in mice.

Keri Barron, Besim Ogretmen, Natalia Krupenko

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutritional biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Keri BarronNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina.
Besim OgretmenDepartment of Biochemistry & Molecular Biology, Hollings Cancer center, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina.
Natalia KrupenkoNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina,; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina,. Electronic address: natalia_krupenko@unc.edu.
University of North Carolina at Chapel Hill · USMedical University of South Carolina · US

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7M
THE ROLE OF LACTOSYLCERAMIDE IN RENAL AGING AND DISEASEP20RR017677 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MAO, CUNGUI · 2002 to 2011
$23.4M
Project 3: Targeting SK2/S1P Signaling for the Regulation of c-Myc and Tumor SuppressionP01CA203628 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BIELAWSKA, ALICJA · 2016 to 2021
$8.9M
Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and TherapyR01DE016572 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI OGRETMEN, BESIM · 2005 to 2025
$7.4M
Research Supplement to Promote Diversity in Health-Related ResearchR01CA214461 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Besim Ogretmen · 2018 to 2026
$3.3M
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR018823 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND, JOHN R · 2003 to 2003
$2.9M
Ceramide signaling in the regulation of cellular response to folate stressR01CA193782 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KRUPENKO, NATALIA IVANOVNA · 2015 to 2019
$1.7M
NCI NIH HHS P01 CA203628NCI NIH HHS P30 CA138313NCI NIH HHS R01 CA193782NCI NIH HHS R01 CA214461NCRR NIH HHS C06 RR018823NCRR NIH HHS P20 RR017677NIDCR NIH HHS R01 DE016572
6 · The paper itself

Abstract

Folic acid-fortified foods and multi-vitamin supplements containing folic acid (FA) are widely used around the world, but the exact mechanisms/metabolic effects of FA are not precisely identified. We have demonstrated that Ceramide Synthase 6 (CerS6) and C

Indexed as

AnimalsApoptosisCell Line, TumorCeramidesChromatography, LiquidDietFemaleFolic AcidLiverMaleMetabolomeMiceOxidoreductasesSex FactorsSphingolipidsSphingomyelinsCeramidesCERS6 protein, mousedihydroceramide desaturaseFolic AcidOxidoreductasesSphingolipidsSphingomyelinsSphingosine N-AcyltransferaseCeramide synthase 6Dietary folateMetabolic healthMetabolomeSex differenceSphingolipid

Identifiers

PMID34358645
PMCPMC8571033
OpenAlexW3191596098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.