Evidence map›Paper›PMID 34358566›Full record

ArticleThe Journal of biological chemistry2021

Actinobacillus utilizes a binding protein-dependent ABC transporter to acquire the active form of vitamin B

Chuxi Pan, Alexandra Zimmer, Megha Shah, Minh Sang Huynh, Christine Chieh-Lin Lai, Brandon Sit, Yogesh Hooda, David M Curran, Trevor F Moraes

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. microRNA maintains nutrient homeostasis in the symbiont-host interaction.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Chuxi PanDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Alexandra ZimmerDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Megha ShahDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Minh Sang HuynhDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Christine Chieh-Lin LaiDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Brandon SitDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Yogesh HoodaDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
David M CurranDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Trevor F MoraesDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada. Electronic address: trevor.moraes@utoronto.ca.
University of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria require high-efficiency uptake systems to survive and proliferate in nutrient-limiting environments, such as those found in host organisms. ABC transporters in the bacterial plasma membrane provide a mechanism for transport of many substrates. In this study, we examine an operon containing a periplasmic binding protein in Actinobacillus for its potential role in nutrient acquisition. The electron density map of 1.76 Å resolution obtained from the crystal structure of the periplasmic binding protein was best fit with a molecular model containing a pyridoxal-5'-phosphate (P5P/pyridoxal phosphate/the active form of vitamin B

Indexed as

Actinobacillus pleuropneumoniaeATP-Binding Cassette TransportersBacterial ProteinsBinding SitesBiological TransportEscherichia coliModels, MolecularOperonPeriplasmic Binding ProteinsPyridoxal PhosphateVitamin B 6ATP-Binding Cassette TransportersBacterial ProteinsPeriplasmic Binding ProteinsPyridoxal PhosphateVitamin B 6Gram-negative bacteriaperiplasmic binding proteinprotein transporterspyrodoxial-5-phosphate uptake

Identifiers

PMID34358566
PMCPMC8427247
OpenAlexW3187753422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.