Evidence map›Paper›PMID 34358564›Full record

ArticleThe Journal of biological chemistry2021

Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire.

Ketan D Patel, Andrew M Gulick

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ketan D PatelDepartment of Structural Biology, Jacobs School of Medicine and Biological Sciences, University at Buffalo, Buffalo, New York, USA.
Andrew M GulickDepartment of Structural Biology, Jacobs School of Medicine and Biological Sciences, University at Buffalo, Buffalo, New York, USA. Electronic address: amgulick@buffalo.edu.
University at Buffalo, State University of New York · US

Funding

Structural Studies of Nonribosomal Peptide SynthesisR35GM136235 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI GULICK, ANDREW M · 2020 to 2024
$2.0M
NIGMS NIH HHS R35 GM136235
6 · The paper itself

Abstract

The study of natural products provides exciting opportunities for the discovery of novel biologically active molecules and biosynthetic pathways. Recently, Yuan and colleagues described 30 cyclic depsipeptides that are biosynthesized by proteins encoded by three distinct gene clusters in the marine fungus, Beauveria felina. Genetic and biochemical studies confirmed the involvement of nonribosomal peptide synthetases in the production of multiple compounds, some of which inhibit Zika virus replication.

Indexed as

BeauveriaDepsipeptidesZika VirusZika Virus InfectionBiosynthetic PathwaysHumansPeptide SynthasesDepsipeptidesPeptide Synthases

Identifiers

PMID34358564
PMCPMC8384895
OpenAlexW3190601417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.