Evidence map›Paper›PMID 34358489›Full record

ReviewGastroenterology2021

Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.

Gerhard Rogler, Abha Singh, Arthur Kavanaugh, David T Rubin

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07247994 (Neurological Manifestations in Children Diagnosed With Inflammatory Bowel Disease in Assiut University Child Hospital), which is not on this map. Cited by 488 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
488citing papers in PubMed, 11 pooled it
73.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07247994 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Neurological Manifestations in Children Diagnosed With Inflammatory Bowel Disease in Assiut University Child Hospital

Typeobservational_patient_registrySponsorBishoy Shehata FahimRan2026 to 2027Enrolled44ConditionsIBD (Inflammatory Bowel Disease)
3 · Its place in the literature

Who cites it

488 citing papers in PubMed, 11 syntheses or guidelines pooled it, 776 citations in OpenAlex.

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  6. Short-chain fatty acids in the treatment of ulcerative colitis. Systematic review and meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
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428 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Gerhard RoglerDepartment of Gastroenterology and Hepatology, Department of Medicine, Zurich University Hospital, Zurich, Switzerland.
Abha SinghUniversity of California, San Diego, La Jolla, California.
Arthur KavanaughUniversity of California, San Diego, La Jolla, California.
David T RubinUniversity of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois. Electronic address: drubin@uchicago.edu.
University of California San Diego · USUniversity Hospital of Zurich · CHUniversity of Chicago · US

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
NIDDK NIH HHS P30 DK042086
6 · The paper itself

Abstract

Inflammatory bowel diseases (IBDs) are systemic diseases that manifest not only in the gut and gastrointestinal tract, but also in the extraintestinal organs in many patients. The quality of life for patients with IBD can be substantially affected by these extraintestinal manifestations (EIMs). It is important to have knowledge of the prevalence, pathophysiology, and clinical presentation of EIMs in order to adapt therapeutic options to cover all aspects of IBD. EIMs can occur in up to 24% of patients with IBD before the onset of intestinal symptoms, and need to be recognized to initiate appropriate diagnostic procedures. EIMs most frequently affect joints, skin, or eyes, but can also affect other organs, such as the liver, lung, and pancreas. It is a frequent misconception that a successful therapy of the intestinal inflammation will be sufficient to treat EIMs satisfactorily in most patients with IBD. In general, peripheral arthritis, oral aphthous ulcers, episcleritis, or erythema nodosum can be associated with active intestinal inflammation and can improve on standard treatment of the intestinal inflammation. However, anterior uveitis, ankylosing spondylitis, and primary sclerosing cholangitis usually occur independent of disease flares. This review provides a comprehensive overview of epidemiology, pathophysiology, clinical presentation, and treatment of EIMs in IBD.

Indexed as

Anti-Inflammatory AgentsHumansImmunomodulating AgentsInflammatory Bowel DiseasesPredictive Value of TestsQuality of LifeRemission InductionRisk AssessmentRisk FactorsSymptom AssessmentTreatment OutcomeAnti-Inflammatory AgentsImmunomodulating AgentsArthralgiasArthritisCrohn’s DiseaseErythema NodosumExtraintestinal ManifestationsInflammatory Bowel DiseasePrimary Sclerosing CholangitisPsoriasisPyoderma GangrenosumSpondyloarthropathyUlcerative ColitisUveitis

Identifiers

PMID34358489
PMCPMC8564770
OpenAlexW3190932060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.