Evidence map›Paper›PMID 34358457›Full record

ArticleMolecular cell2021

Transcription and topoisomerases bring new twists to DNA loop extrusion by cohesin.

Rini Shah, Elphège P Nora

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Rini ShahCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Elphège P NoraCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. Electronic address: elphege.nora@ucsf.edu.

Funding

Investigating the role of genome folding in transcriptional regulationR35GM142792 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NORA, ELPHEGE-PIERRE JULIEN · 2021 to 2025
$2.0M
NIGMS NIH HHS R35 GM142792
6 · The paper itself

Abstract

Neguembor et al. (2021) use super-resolution microscopy to illuminate genome packaging inside the cell nucleus. They discover that transcription and topoisomerases protect chromatin from collapsing in a crumpled state refractory to DNA loop extrusion by cohesin proteins.

Indexed as

Cell Cycle ProteinsChromosomal Proteins, Non-HistoneChromatinCohesinsDNAHumansCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsDNA

Identifiers

PMID34358457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.