ArticleCurrent biology : CB2021
Cell-type-specific Hox regulatory strategies orchestrate tissue identity.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- HOXA5-driven transcriptional program in lung development.Developmental biology · 2025Article
- The homeobox transcription factor MNX1 regulates the expression of many non-MN-specific neuronal genes in motor neurons.Nucleic acids research · 2025Article
- Biology of Hox Genes: Questions and Technological Challenges.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Novel Antennapedia and Ultrabithorax trimeric complexes with TBP and Exd regulate transcription.Hereditas · 2024Article
- Article
- Article
- Transcription factor interactions explain the context-dependent activity of CRX binding sites.PLoS computational biology · 2024Article
- A Micro-evolutionary Change in Target Binding Sites as a Key Determinant of Ultrabithorax Function in Drosophila.Journal of molecular evolution · 2023Article
- Role of the Hox Genes,International journal of molecular sciences · 2023Article
- Overexpression ofInternational journal of molecular sciences · 2023Article
- Enhancer architecture and chromatin accessibility constrain phenotypic space during Drosophila development.Developmental cell · 2023Article
- Hox genes in development and beyond.Development (Cambridge, England) · 2023Article
- Characterisation of the role and regulation ofFrontiers in cell and developmental biology · 2023Article
- Flight or protection: the genesProceedings. Biological sciences · 2022Article
- Divergent expression of paralogous genes by modification of shared enhancer activity through a promoter-proximal silencer.Current biology : CB · 2022Article
- Different transcriptional responses by the CRISPRa system in distinct types of heterochromatin in Drosophila melanogaster.Scientific reports · 2022Article
- SpyChIP identifies cell type-specific transcription factor occupancy from complex tissues.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Trimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional activity.Hereditas · 2022Article
- Fluorescent labeling of genomic loci inCell reports methods · 2022Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Hox proteins are homeodomain transcription factors that diversify serially homologous segments along the animal body axis, as revealed by the classic bithorax phenotype of Drosophila melanogaster, in which mutations in Ultrabithorax (Ubx) transform the third thoracic segment into the likeness of the second thoracic segment. To specify segment identity, we show that Ubx both increases and decreases chromatin accessibility, coinciding with its dual role as both an activator and repressor of transcription. However, the choice of transcriptional activity executed by Ubx is spatially regulated and depends on the availability of cofactors, with Ubx acting as a repressor in some populations and as an activator in others. Ubx-mediated changes to chromatin accessibility positively and negatively affect the binding of Scalloped (Sd), a transcription factor that is required for appendage development in both segments. These findings illustrate how a single Hox protein can modify complex gene regulatory networks to transform the identity of an entire tissue.
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Registered trials
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