ArticlePLoS neglected tropical diseases2021
The changing epidemiology of hemorrhagic fever with renal syndrome in Southeastern China during 1963-2020: A retrospective analysis of surveillance data.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Bleeding in haemorrhagic fever with renal syndrome: A systematic review characterising the loss of haemostasis in hantavirus infections.PLoS neglected tropical diseases · 2026Pooled it
- Incidence rate of hemorrhagic fever with renal syndrome complicated with acute pancreatitis: a meta-analysis.Frontiers in medicine · 2024Pooled it
- Article
- Clinical Value the Neutrophil CD64 Index in Predicting the Severity of Hemorrhagic Fever With Renal Syndrome.Immunity, inflammation and disease · 2026Article
- Spatiotemporal pattern of hemorrhagic fever with renal syndrome and driving factors in Shandong Province of China, 2018-2024.PLoS neglected tropical diseases · 2026Article
- Impact of hemorrhagic fever with renal syndrome control policies in Hebei Province: an interrupted time series analysis.BMC infectious diseases · 2026Article
- Spatio-temporal clustering and meteorological factors influencing HFRS incidence in mainland China, 2004-2021.Epidemiology and infection · 2025Article
- Hantaan virus-derived peptides that stabilize HLA-E could abrogate inhibition of CD56dimNKG2A+ NK cells.PLoS pathogens · 2025Article
- Epidemiological Characteristics of Hemorrhagic Fever with Renal Syndrome in Longyou County, China.Viruses · 2025Article
- Meteorological drivers of hemorrhagic fever with renal syndrome in China's Jiaodong Peninsula: an ecological time-series study from 2020 to 2024.Frontiers in public health · 2025Article
- DNA Vaccines Encoding HTNV GP-Derived Th Epitopes Benefited from a LAMP-Targeting Strategy and Established Cellular Immunoprotection.Vaccines · 2024Article
- Epidemiology of Hemorrhagic Fever with Renal Syndrome and Host Surveillance in Zhejiang Province, China, 1990-2021.Viruses · 2024Article
- HLA-E-restricted Hantaan virus-specific CD8Biosafety and health · 2023Article
- Annual incidence and fatality rates of notifiable infectious diseases in southeast China from 1950 to 2022 and relationship to socioeconomic development.Journal of global health · 2023Article
- Orthohantavirus infections in humans and rodents in the Yichun region, China, from 2016 to 2021.PLoS neglected tropical diseases · 2023Article
- Article
- Epidemiological characteristics and prediction model construction of hemorrhagic fever with renal syndrome in Quzhou City, China, 2005-2022.Frontiers in public health · 2023Article
- Analysis of the effect of meteorological factors on hemorrhagic fever with renal syndrome in Taizhou City, China, 2008-2020.BMC public health · 2022Article
- Factors associated with hemorrhagic fever with renal syndrome based maximum entropy model in Zhejiang Province, China.Frontiers in medicine · 2022Article
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease caused by hantavirus which was endemic Zhejiang Province, China. In this study, we aim to explore the changing epidemiology of HFRS in Zhejiang, identify high-risk areas and populations, and evaluate relevant policies and interventions to better improve HFRS control and prevention.
methodsSurveillance data on HFRS during 1963-2020 in Zhejiang Province were extracted from Zhejiang Provincial Center for Disease Control and Prevention archives and the Chinese Notifiable Disease Reporting System. The changing epidemiological characteristics of HFRS including seasonal distribution, geographical distribution, and demographic features, were analyzed using joinpoint regression, autoregressive integrated moving average model, descriptive statistical methods, and Spatio-temporal cluster analysis.
resultsFrom 1963 to 2020, 114 071 HFRS cases and 1269 deaths were reported in Zhejiang Province. The incidence increased sharply from 1973 and peaked in 1986, then decreased steadily and maintained a stable incidence from 2004. HFRS cases were reported in all 11 prefecture-level cities of Zhejiang Province from 1963 to 2020. The joint region (Shengzhou, Xinchang, Tiantai, and surrounding areas), and Kaihua County are the most seriously affected regions throughout time. After 1990, the first HFRS incidence peak was in May-June, with another one from November to January. Most HFRS cases occurred in 21- (26.48%) and 30- years group (24.25%) from 1991 to 2004, but 41- (25.75%) and 51-years (23.30%) had the highest proportion from 2005 to 2020. Farmers accounted for most cases (78.10%), and cases are predominantly males with a male-to-female ratio of 2.6:1. It was found that the median time from onset to diagnosis was 6.5 days (IQR 3.75-10.42), and the time from diagnosis to disease report was significantly shortened after 2011.
conclusionsWe observed dynamic changes in the seasonal distribution, geographical distribution, and demographic features of HFRS, which should be well considered in the development of control and prevention strategies in future. Additional researches are warranted to elucidate the environmental, meteorological, and social factors associated with HFRS incidence in different decades.
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