Evidence map›Paper›PMID 34358138›Full record

ArticleVaccines2021

Influenza A Virus Hemagglutinin Trimer, Head and Stem Proteins Identify and Quantify Different Hemagglutinin-Specific B Cell Subsets in Humans.

Aafke Aartse, Dirk Eggink, Mathieu Claireaux, Sarah van Leeuwen, Petra Mooij, Willy M Bogers, Rogier W Sanders, Gerrit Koopman, Marit J van Gils

Abstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aafke AartseDepartment of Virology, Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands.
Dirk EgginkDepartment of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Mathieu ClaireauxDepartment of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Sarah van LeeuwenDepartment of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Petra MooijDepartment of Virology, Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands.ORCID 0000-0001-8608-8629
Willy M BogersDepartment of Virology, Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands.ORCID 0000-0002-4563-8513
Rogier W SandersDepartment of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Gerrit KoopmanDepartment of Virology, Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands.ORCID 0000-0002-3428-5978
Marit J van GilsDepartment of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0003-3422-8161

Funding

AMC Fellowship, Amsterdam UMC #2017Netherlands Organization for Scientific Research (NWO) Vici grant #91818627
6 · The paper itself

Abstract

Antibody responses against the influenza A virus hemagglutinin (HA)-protein are studied intensively because they can protect against (re)infection. Previous studies have focused on antibodies targeting the head or stem domains, while other possible specificities are often not taken into account. To study such specificities, we developed a diverse set of HA-domain proteins based on an H1N1

Indexed as

antibody responsesheadhemagglutinininfluenza A virusstemtrimer specific

Identifiers

PMID34358138
PMCPMC8310015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.